Abstract Treatment of tuberculosis (TB) involves the administration of anti-mycobacterial
drugs for several months. The emergence of drug-resistant strains of Mycobacterium …

Tuberculosis is a far-reaching, high-impact disease. It is among the top ten causes of death
worldwide caused by a single infectious agent; 1.6 million tuberculosis-related deaths were …

Rationale Bedaquiline has been classified as a group A drug for the treatment of multidrug-
resistant tuberculosis (MDR-TB) by the World Health Organization; however, globally …

The hallmark of tuberculosis (TB) is the formation of immune cell-enriched aggregates called
granulomas. While granulomas are pathologically diverse, their tissue-wide heterogeneity …

Background Bacterial diversity could contribute to the diversity of tuberculosis infection and
treatment outcomes observed clinically, but the biological basis of this association is poorly …

Mycobacterium tuberculosis (M. tb) is a bacterial pathogen that has evolved in humans, and
its interactions with the host are complex and best studied in humans. Myriad immune …

English Language (EL) is a core subject in schools, and success in it is a part of the
requirements for certification and educational advancement. However, evidence has shown …

BACKGROUND Matrix metalloproteinases (MMPs) are key regulators of tissue destruction in
tuberculosis (TB) and may be targets for host-directed therapy. We conducted a phase II …

Research on the pathogenesis of tuberculosis (TB) has been hamstrung for half a century by
the paradigm that granulomas are the hallmark of active disease. Human TB, in fact …

Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis (TB), is one of
the most successfully adapted human pathogens. Human-to-human transmission occurs at …