Therapeutic resistance continues to be an indominable foe in our ambition for curative
cancer treatment. Recent insights into the molecular determinants of acquired treatment …

The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

All cancers emerge after a period of clonal selection and subsequent clonal expansion.
Although the evolutionary principles imparted by genetic intratumour heterogeneity are …

Posttranslational modifications add tremendous complexity to proteomes; however, gaps
remain in knowledge regarding the function and regulatory mechanism of newly discovered …

Comparing single-cell transcriptomic atlases from diverse organisms can elucidate the
origins of cellular diversity and assist the annotation of new cell atlases. Yet, comparison …

The dysregulation of developmental and stem cell–associated genes is a common
phenomenon during cancer development. Around half of patients with acute myeloid …

Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

Understanding the genetic and epigenetic bases of cellular senescence is instrumental in
develo** interventions to slow aging. We performed genome-wide CRISPR-Cas9–based …

The development and immune evasion of cancer stem cells (CSCs) limit the efficacy of
currently available anticancer therapies. Recent studies have shown that epigenetic …

Lysine (Lys) residues in proteins undergo a wide range of reversible post-translational
modifications (PTMs), which can regulate enzyme activities, chromatin structure, protein …