Understanding 3D genome organization by multidisciplinary methods
Understanding how chromatin is folded in the nucleus is fundamental to understanding its
function. Although 3D genome organization has been historically difficult to study owing to a …
function. Although 3D genome organization has been historically difficult to study owing to a …
Methods for map** 3D chromosome architecture
R Kempfer, A Pombo - Nature Reviews Genetics, 2020 - nature.com
Determining how chromosomes are positioned and folded within the nucleus is critical to
understanding the role of chromatin topology in gene regulation. Several methods are …
understanding the role of chromatin topology in gene regulation. Several methods are …
Ever-changing landscapes: transcriptional enhancers in development and evolution
A class of cis-regulatory elements, called enhancers, play a central role in orchestrating
spatiotemporally precise gene-expression programs during development. Consequently …
spatiotemporally precise gene-expression programs during development. Consequently …
The 3D genome as moderator of chromosomal communication
Proper expression of genes requires communication with their regulatory elements that can
be located elsewhere along the chromosome. The physics of chromatin fibers imposes a …
be located elsewhere along the chromosome. The physics of chromatin fibers imposes a …
The relationship between genome structure and function
Precise patterns of gene expression in metazoans are controlled by three classes of
regulatory elements: promoters, enhancers and boundary elements. During differentiation …
regulatory elements: promoters, enhancers and boundary elements. During differentiation …
Principles of genome folding into topologically associating domains
Understanding the mechanisms that underlie chromosome folding within cell nuclei is
essential to determine the relationship between genome structure and function. The recent …
essential to determine the relationship between genome structure and function. The recent …
[HTML][HTML] CTCF binding polarity determines chromatin loo**
CCCTC-binding factor (CTCF) is an architectural protein involved in the three-dimensional
(3D) organization of chromatin. In this study, we assayed the 3D genomic contact profiles of …
(3D) organization of chromatin. In this study, we assayed the 3D genomic contact profiles of …
CTCF and cohesin in genome folding and transcriptional gene regulation
Genome function, replication, integrity, and propagation rely on the dynamic structural
organization of chromosomes during the cell cycle. Genome folding in interphase provides …
organization of chromosomes during the cell cycle. Genome folding in interphase provides …
Insulated neighborhoods: structural and functional units of mammalian gene control
Understanding how transcriptional enhancers control over 20,000 protein-coding genes to
maintain cell-type-specific gene expression programs in all human cells is a fundamental …
maintain cell-type-specific gene expression programs in all human cells is a fundamental …
Breaking TADs: how alterations of chromatin domains result in disease
Spatial organization is an inherent property of the vertebrate genome to accommodate the
roughly 2m of DNA in the nucleus of a cell. In this nonrandom organization, topologically …
roughly 2m of DNA in the nucleus of a cell. In this nonrandom organization, topologically …