Mitochondrial dysfunction in Parkinson's disease–a key disease hallmark with therapeutic potential

MT Henrich, WH Oertel, DJ Surmeier… - Molecular …, 2023‏ - Springer
Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

Role of heavy metals (copper (Cu), arsenic (As), cadmium (Cd), iron (Fe) and lithium (Li)) induced neurotoxicity

B Vellingiri, A Suriyanarayanan, P Selvaraj… - Chemosphere, 2022‏ - Elsevier
Parkinson's disease (PD) is a neurodegenerative condition characterized by the dopamine
(DA) neuronal loss in the substantia nigra. PD impairs motor controls symptoms such as …

Iron deposition in parkinson's disease: A mini-review

W Zeng, J Cai, L Zhang, Q Peng - Cellular and molecular neurobiology, 2024‏ - Springer
Iron deposition is crucial pathological changes observed in patients with Parkinson's
disease (PD). Recently, scientists have actively explored therapeutic approaches targeting …

A brief history of brain iron accumulation in Parkinson disease and related disorders

PB Foley, DJ Hare, KL Double - Journal of Neural Transmission, 2022‏ - Springer
Iron has a long and storied history in Parkinson disease and related disorders. This
essential micronutrient is critical for normal brain function, but abnormal brain iron …

Challenges and opportunities of metal chelation therapy in trace metals overload-induced Alzheimer's disease

V Chaudhari, S Bagwe-Parab, HS Buttar, S Gupta… - Neurotoxicity …, 2023‏ - Springer
Essential trace metals like zinc (Zn), iron (Fe), and copper (Cu) play an important
physiological role in the metabolomics and healthy functioning of body organs, including the …

The role of iron metabolism, lipid metabolism, and redox homeostasis in Alzheimer's disease: from the perspective of ferroptosis

L Wu, X **an, Z Tan, F Dong, G Xu, M Zhang… - Molecular …, 2023‏ - Springer
In the development of Alzheimer's disease (AD), cell death is common. Novel cell death form—
ferroptosis is discovered in recent years. Ferroptosis is an iron-regulated programmed cell …

Conservative iron chelation for neurodegenerative diseases such as Parkinson's disease and amyotrophic lateral sclerosis

D Devos, ZI Cabantchik, C Moreau, V Danel… - Journal of Neural …, 2020‏ - Springer
Focal iron accumulation associated with brain iron dyshomeostasis is a pathological
hallmark of various neurodegenerative diseases (NDD). The application of iron-sensitive …

Prevention of progression in Parkinson's disease

J Aaseth, P Dusek, PM Roos - Biometals, 2018‏ - Springer
Environmental influences affecting genetically susceptible individuals seem to contribute
significantly to the development of Parkinson's disease (PD). Xenobiotic exposure including …

[HTML][HTML] New hopes for disease modification in Parkinson's Disease

W Poewe, K Seppi, K Marini, P Mahlknecht - Neuropharmacology, 2020‏ - Elsevier
To date, despite numerous clinical trials, no intervention has been demonstrated to modify
the progression of Parkinson's disease (PD). However, over the past decades encouraging …

Iron toxicity, ferroptosis and microbiota in Parkinson's disease: Implications for novel targets

FV Carvalho, HE Landis, B Getachew, VDA Silva… - Advances in …, 2024‏ - Elsevier
Parkinson's Disease (PD) is a progressive neurodegenerative disease characterized by loss
of dopaminergic neurons in substantia nigra pars compacta (SNpc). Iron (Fe)-dependent …