Current advance of nanotechnology in diagnosis and treatment for malignant tumors

B Wang, S Hu, Y Teng, J Chen, H Wang, Y Xu… - … and Targeted Therapy, 2024 - nature.com
Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary
field that is garnering a lot of interest and investigation. Nanomedicine shows great potential …

Extrahepatic targeting of lipid nanoparticles in vivo with intracellular targeting for future nanomedicines

T Nakamura, Y Sato, Y Yamada… - Advanced drug delivery …, 2022 - Elsevier
A new era of nanomedicines that involve nucleic acids/gene therapy has been opened after
two decades in 21st century and new types of more efficient drug delivery systems (DDS) …

mRNA nanodelivery systems: targeting strategies and administration routes

M Yuan, Z Han, Y Liang, Y Sun, B He… - Biomaterials …, 2023 - spj.science.org
With the great success of coronavirus disease (COVID-19) messenger ribonucleic acid
(mRNA) vaccines, mRNA therapeutics have gained significant momentum for the prevention …

Expanding RNAi to kidneys, lungs, and spleen via selective ORgan targeting (SORT) siRNA lipid nanoparticles

A Vaidya, S Moore, S Chatterjee, E Guerrero… - Advanced …, 2024 - Wiley Online Library
Inhibition of disease‐causing mutations using RNA interference (RNAi) has resulted in
clinically approved medicines with additional candidates in late stage trials. However …

An overview of the stability and delivery challenges of commercial nucleic acid therapeutics

RG Ingle, WJ Fang - Pharmaceutics, 2023 - mdpi.com
Nucleic acid (NA)-based biopharmaceuticals have emerged as promising therapeutic
modalities. NA therapeutics are a diverse class of RNA and DNA and include antisense …

Inhaled drug delivery: Past, present, and future

L Yue, X Zhang, C Zhao, R Chen, X Chen, L Rao - Nano Today, 2023 - Elsevier
Inhaled drug delivery has been an emerging route for the treatment of lung diseases with
clear advantages over oral and intravenous routes. However, the delivery efficacy is affected …

Nebulized Inhalation of Peptide-Modified DNA Origami To Alleviate Acute Lung Injury

H Wang, Y Jiao, S Ma, Z Li, J Gong, Q Jiang… - Nano Letters, 2024 - ACS Publications
Acute lung injury (ALI) is a severe inflammatory lung disease, with high mortality rates. Early
intervention by reactive oxygen species (ROS) scavengers could reduce ROS accumulation …

Progress on the pathological tissue microenvironment barrier-modulated nanomedicine

H Han, L **ng, BT Chen, Y Liu, TJ Zhou, Y Wang… - Advanced Drug Delivery …, 2023 - Elsevier
Imbalance in the tissue microenvironment is the main obstacle to drug delivery and
distribution in the human body. Before penetrating the pathological tissue microenvironment …

Recent progress of iron-based nanomaterials in gene delivery and tumor gene therapy

Y Gong, X Hu, M Chen, J Wang - Journal of Nanobiotechnology, 2024 - Springer
Gene therapy aims to modify or manipulate gene expression and change the biological
characteristics of living cells to achieve the purpose of treating diseases. The safe, efficient …

[HTML][HTML] Aerosol delivery of star polymer-siRNA nanoparticles as a therapeutic strategy to inhibit lung tumor growth

Z Ma, SW Wong, H Forgham, L Esser, M Lai… - Biomaterials, 2022 - Elsevier
Lung cancer is a major contributor to cancer-related death worldwide. siRNA
nanomedicines are powerful tools for cancer therapeutics. However, there are challenges to …