Oxidative stress plays a crucial role in aging-related eye diseases, including age-related
macular degeneration (AMD), cataracts, and glaucoma. With age, antioxidant reparative …

Inflammation is a cellular response to factors that challenge the homeostasis of cells and
tissues. Cell-associated and soluble pattern-recognition receptors, eg Toll-like receptors …

Background Geographic atrophy is a leading cause of progressive, irreversible vision loss.
The objectives of OAKS and DERBY were to assess the efficacy and safety of …

Background Intravitreal aflibercept 8 mg could improve treatment outcomes and provide
sustained disease control in patients with neovascular age-related macular degeneration …

Abstract Objective An independent Safety Review Committee (SRC; supported by Novartis
Pharma AG [Basel, Switzerland]) analyzed investigator-reported cases of intraocular …

Purpose To report the 96-week outcomes from HAWK and HARRIER. Design Phase 3,
prospective, randomized, double-masked, multicenter studies comparing efficacy and safety …

Purpose To evaluate 2-year efficacy, durability, and safety of the bispecific antibody
faricimab, which inhibits both angiopoietin-2 and VEGF-A. Design TENAYA (ClinicalTrials …

Purpose To evaluate features and outcomes of eyes with retinal vasculitis and intraocular
inflammation (IOI) after intravitreal injection (IVI) of brolucizumab 6 mg/0.05 ml for treatment …

Purpose To provide 2-year results comparing anti–vascular endothelial growth factor
(VEGF) agents for center-involved diabetic macular edema (DME) using a standardized …

Purpose To describe outcomes 5 years after initiating treatment with bevacizumab or
ranibizumab for neovascular age-related macular degeneration (AMD). Design Cohort …