To understand the placement of a certain protein in a physiological system and the
pathogenesis of related disorders, it is not only of interest to determine its function but also …

Several important physiological processes, from permeability to inflammation to hemostasis,
take place at the vessel wall and are regulated by endothelial cells (ECs). Thus, proteins that …

Background Prolonged recovery is common after acute SARS‐CoV‐2 infection; however,
the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown …

Summary von Willebrand factor (VWF) is a protein best known from its critical role in
hemostasis. Indeed, any dysfunction of VWF is associated with a severe bleeding tendency …

Abstract Weibel-Palade bodies (WPBs) are elongated secretory organelles specific to
endothelial cells that contain von Willebrand factor (VWF) and a variety of other proteins that …

Arthropathy is a frequent and serious complication of repeated joint bleeding in patients with
hemophilia, resulting in pain, deformity, and disability. Although the pathogenesis of …

The plasma glycoprotein von Willebrand factor (VWF) is exclusively synthesized in
endothelial cells (ECs) and megakaryocytes, the precursor cells of platelets. Its primary …

Osteoprotegerin (OPG) is an essential secreted protein in bone turnover due to its role as a
decoy receptor for the Receptor Activator of Nuclear Factor-kB ligand (RANKL) in the …

Abstract von Willebrand factor (VWF) is amongst others synthesized by endothelial cells and
stored as ultra-large (UL) VWF multimers in Weibel-Palade bodies. Although UL-VWF is …

In 2007, 1179 papers were published that involved the application of optical biosensors.
Reported developments in instrument hardware, assay design, and immobilization …