Platforms, advances, and technical challenges in virus-like particles-based vaccines

R Gupta, K Arora, SS Roy, A Joseph… - Frontiers in …, 2023 - frontiersin.org
Viral infectious diseases threaten human health and global stability. Several vaccine
platforms, such as DNA, mRNA, recombinant viral vectors, and virus-like particle-based …

Yeast-based virus-like particles as an emerging platform for vaccine development and delivery

V Srivastava, KN Nand, A Ahmad, R Kumar - Vaccines, 2023 - mdpi.com
Virus-like particles (VLPs) are empty, nanoscale structures morphologically resembling
viruses. Internal cavity, noninfectious, and particulate nature with a high density of repeating …

A global survey in the developmental landscape of possible vaccination strategies for COVID-19

A Gasmi, S Srinath, M Dadar, L Pivina, A Menzel… - Clinical …, 2022 - Elsevier
The development of COVID-19 vaccines was promptly regulated to ensure the best possible
approach. By January 2022, 75 candidates reached preclinical evaluation in various animal …

Unlocking potential: virus-like particles as a promising strategy for effective HCV vaccine development

AA Ali, AA Tabll - Virology, 2024 - Elsevier
Hepatitis C virus (HCV) is a leading cause of liver disease worldwide. The development of
prophylactic vaccine is essential for HCV global eradication. Despite over three decades of …

Novel therapeutic approaches for the management of hepatitis infections

A Damodaran, SM Zachariah, SC Nair - Therapeutic Delivery, 2024 - Taylor & Francis
Hepatitis B virus (HBV) & hepatitis C virus (HCV) infection is a substantial reason for
morbidity and mortality around the world. Chronic hepatitis B (CHB) infection is connected …

Two-component vaccine consisting of virus-like particles displaying hepatitis C virus envelope protein 2 oligomers

J Prentoe, CM Janitzek, R Velázquez-Moctezuma… - npj Vaccines, 2022 - nature.com
Abstract Development of B-cell-based hepatitis C virus (HCV) vaccines that induce broadly
neutralizing antibodies (bNAbs) is hindered by extensive sequence diversity and low …

[HTML][HTML] Yeast and Virus-like Particles: A Perfect or Imperfect Couple?

S Brachelente, A Galli, T Cervelli - Applied Microbiology, 2023 - mdpi.com
Virus-like particles (VLPs) comprise viral structural proteins that self-assemble to form a
particle similar to the native virus capsid. Since their discovery, they have been employed …

Immunity of two novel hepatitis C virus polyepitope vaccines

T Feng, M Li, L Zhang, S Li, Z Yang, L Kang, Y Guo… - Vaccine, 2022 - Elsevier
Hepatitis C virus (HCV) infection remains a serious public health burden around the world.
So far there is no effective vaccine against this virus. Neutralizing antibody (NAb) responses …

Advances in Tumor Antigen‐Based Anticancer Immunotherapy: Recent Progress, Prevailing Challenges, and Future Perspective

W Shi, S Chen, F Chi, Q Qiu, Y Zhong… - Advanced …, 2023 - Wiley Online Library
Elimination of tumors by regulating the immune system is the primary research focus in the
rapidly develo** field of immune‐oncology. Current immunotherapeutic strategies mainly …

Bioinformatics Insights on the Physicochemical Properties of Hepatitis Virus Envelope Glycoproteins

C Polanco, A Huberman, VN Uversky… - Letters in Drug …, 2024 - benthamdirect.com
Background Globally, hepatitis B and C infect 400 million people, more than 10 times the
number of people living with HIV. In 2019, it was estimated that 1.1 million people died as a …