Use of analgesics/antipyretics in the management of symptoms associated with COVID-19 vaccination

EE Ooi, A Dhar, R Petruschke, C Locht, P Buchy… - npj Vaccines, 2022 - nature.com
COVID-19 vaccines are effective and important to control the ongoing pandemic, but vaccine
reactogenicity may contribute to poor uptake. Analgesics or antipyretic medications are often …

Let fever do its job: the meaning of fever in the pandemic era

S Wrotek, EK LeGrand, A Dzialuk… - Evolution, medicine, and …, 2021 - academic.oup.com
Although fever is one of the main presenting symptoms of COVID-19 infection, little public
attention has been given to fever as an evolved defense. Fever, the regulated increase in …

Nonsteroidal anti-inflammatory drugs dampen the cytokine and antibody response to SARS-CoV-2 infection

JS Chen, MM Alfajaro, RD Chow, J Wei… - Journal of …, 2021 - Am Soc Microbiol
Identifying drugs that regulate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) infection and its symptoms has been a pressing area of investigation during the …

Mechanisms of CD40-dependent cDC1 licensing beyond costimulation

R Wu, RA Ohara, S Jo, TT Liu, ST Ferris, F Ou… - Nature …, 2022 - nature.com
CD40 signaling in classical type 1 dendritic cells (cDC1s) is required for CD8 T cell-
mediated tumor rejection, but the underlying mechanisms are incompletely understood …

Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled …

R Prymula, CA Siegrist, R Chlibek, H Zemlickova… - The Lancet, 2009 - thelancet.com
Background Although fever is part of the normal inflammatory process after immunisation,
prophylactic antipyretic drugs are sometimes recommended to allay concerns of high fever …

Relation of fever intensity and antipyretic use with specific antibody response after two doses of the BNT162b2 mRNA vaccine

N Tani, Y Chong, Y Kurata, K Gondo, R Oishi, T Goto… - Vaccine, 2022 - Elsevier
Background The reactogenicity of BNT162b2 COVID-19 vaccine has been commonly
reported and antipyretic medications are often used for mitigating adverse reactions …

Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells

S Ramon, F Gao, CN Serhan… - The Journal of …, 2012 - journals.aai.org
The resolution of inflammation is an active and dynamic process critical in maintaining
homeostasis. Newly identified lipid mediators have been recognized as key players during …

Effect of antipyretic analgesics on immune responses to vaccination

E Saleh, MA Moody, EB Walter - Human vaccines & …, 2016 - Taylor & Francis
While antipyretic analgesics are widely used to ameliorate vaccine adverse reactions, their
use has been associated with blunted vaccine immune responses. Our objective was to …

Ibuprofen and other widely used non-steroidal anti-inflammatory drugs inhibit antibody production in human cells

S Bancos, MP Bernard, DJ Topham, RP Phipps - Cellular immunology, 2009 - Elsevier
The widely used non-steroidal anti-inflammatory drugs (NSAIDs) function mainly through
inhibition of cyclooxygenases 1 and 2 (Cox-1 and Cox-2). Unlike Cox-1, Cox-2 is considered …

The Aryl Hydrocarbon Receptor Attenuates Tobacco Smoke-induced Cyclooxygenase-2 and Prostaglandin Production in Lung Fibroblasts through Regulation of the …

CJ Baglole, SB Maggirwar, TA Gasiewicz… - Journal of Biological …, 2008 - ASBMB
Diseases such as chronic obstructive pulmonary disease and lung cancer caused by
cigarette smoke affect millions of people worldwide. The aryl hydrocarbon receptor (AhR) is …