The value of antimicrobial peptides in the age of resistance

M Magana, M Pushpanathan, AL Santos… - The lancet infectious …, 2020 - thelancet.com
Accelerating growth and global expansion of antimicrobial resistance has deepened the
need for discovery of novel antimicrobial agents. Antimicrobial peptides have clear …

Antimicrobial peptides immune modulation role in intracellular bacterial infection

DI Duarte-Mata, MC Salinas-Carmona - Frontiers in Immunology, 2023 - frontiersin.org
Intracellular bacteria cause a wide range of diseases, and their intracellular lifestyle makes
infections difficult to resolve. Furthermore, standard therapy antibiotics are often unable to …

Antimicrobial peptides towards clinical application—A long history to be concluded

L Cresti, G Cappello, A Pini - International Journal of Molecular Sciences, 2024 - mdpi.com
Antimicrobial peptides (AMPs) are molecules with an amphipathic structure that enables
them to interact with bacterial membranes. This interaction can lead to membrane crossing …

Host defense peptides: front-line immunomodulators

SC Mansour, OM Pena, REW Hancock - Trends in immunology, 2014 - cell.com
Although first studied for their antimicrobial activity, host defense peptides (HDPs) are now
widely recognized for their multifunctional roles in both the innate and adaptive immune …

Antimicrobial peptides: key components of the innate immune system

M Pasupuleti, A Schmidtchen… - Critical reviews in …, 2012 - Taylor & Francis
Life-threatening infectious diseases are on their way to cause a worldwide crisis, as treating
them effectively is becoming increasingly difficult due to the emergence of antibiotic resistant …

Diff-AMP: tailored designed antimicrobial peptide framework with all-in-one generation, identification, prediction and optimization

R Wang, T Wang, L Zhuo, J Wei, X Fu… - Briefings in …, 2024 - academic.oup.com
Antimicrobial peptides (AMPs), short peptides with diverse functions, effectively target and
combat various organisms. The widespread misuse of chemical antibiotics has led to …

Biological function of antimicrobial peptides on suppressing pathogens and improving host immunity

Z Lyu, P Yang, J Lei, J Zhao - Antibiotics, 2023 - mdpi.com
The emergence of drug-resistant genes and concerns about food safety caused by the
overuse of antibiotics are becoming increasingly prominent. There is an urgent need for …

Role of lipids in the interaction of antimicrobial peptides with membranes

V Teixeira, MJ Feio, M Bastos - Progress in lipid research, 2012 - Elsevier
Antimicrobial peptides (AMPs) take part in the immune system by mounting a first line of
defense against pathogens. Recurrent structural and functional aspects are observed …

Antimicrobial peptides: an introduction

EF Haney, SC Mansour, REW Hancock - Antimicrobial peptides: methods …, 2017 - Springer
The “golden era” of antibiotic discovery has long passed, but the need for new antibiotics
has never been greater due to the emerging threat of antibiotic resistance. This urgency to …

Scorpion venom components as potential candidates for drug development

E Ortiz, GB Gurrola, EF Schwartz, LD Possani - Toxicon, 2015 - Elsevier
Scorpions are well known for their dangerous stings that can result in severe consequences
for human beings, including death. Neurotoxins present in their venoms are responsible for …