Microtubules are pivotal in diverse cellular functions encompassing cell signaling,
morphology, intracellular trafficking, and cell mitosis/division. They are validated targets for …

Cells generate a highly diverse microtubule network to carry out different activities. This
network is comprised of distinct tubulin isotypes, tubulins with different post-translational …

Molecular photoswitches transform light energy into reversible structural changes. Their
combination with known pharmacophores often allows for photomodulation of the biological …

The binding and release of ligands from their protein targets is central to fundamental
biological processes as well as to drug discovery. Photopharmacology introduces chemical …

In this work, we utilized the molecular hybridization strategy to design and synthesize novel
1, 2, 3-triazole benzothiazole derivatives K1-26. The antiproliferative activities against MGC …

Antimitotic agents such as the clinically approved vinca alkaloids, taxanes and epothilone
can arrest cell growth during interphase and are therefore among the most important drugs …

Photochemical regulation provides precise control over enzyme activities with high
spatiotemporal resolution. A promising approach involves anchoring “photoswitches” at …

Retinoic acid receptor‐related orphan receptor γ (RORγ) is a nuclear hormone receptor with
multiple biological functions in circadian clock regulation, inflammation, and immunity. Its …

Living systems utilize sophisticated biochemical regulators and various signal transduction
mechanisms to program bio-molecular assemblies and their associated functions. Creating …

Optical methods to modulate microtubule dynamics show promise for reaching the micron‐
and millisecond‐scale resolution needed to decrypt the roles of the cytoskeleton in biology …