TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
Mechanisms of nanoparticle transport across intestinal tissue: an oral delivery perspective
Oral drug administration has been a popular choice due to patient compliance and limited
clinical resources. Orally delivered drugs must circumvent the harsh gastrointestinal (GI) …
clinical resources. Orally delivered drugs must circumvent the harsh gastrointestinal (GI) …
Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for murine colitis therapy
Background Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by
diffuse inflammation of the colonic mucosa and a relapsing and remitting course. The current …
diffuse inflammation of the colonic mucosa and a relapsing and remitting course. The current …
[HTML][HTML] Charge-reversible and biodegradable chitosan-based microgels for lysozyme-triggered release of vancomycin
Introduction High-dose drug administration for the conventional treatment of inflammatory
bowel disease induces cumulative toxicity and serious side effects. Currently, few reports …
bowel disease induces cumulative toxicity and serious side effects. Currently, few reports …
Oral delivery of natural active small molecules by polymeric nanoparticles for the treatment of inflammatory bowel diseases
M Zu, Y Ma, B Cannup, D **e, Y Jung, J Zhang… - Advanced Drug Delivery …, 2021 - Elsevier
The incidence of inflammatory bowel disease (IBD) is rapidly rising throughout the world.
Although tremendous efforts have been made, limited therapeutics are available for IBD …
Although tremendous efforts have been made, limited therapeutics are available for IBD …
Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome
The gastrointestinal tract (GIT) affects not only local diseases in the GIT but also various
systemic diseases. Factors that can affect the health and disease of both GIT and the human …
systemic diseases. Factors that can affect the health and disease of both GIT and the human …
An effective peptide-based platform for efficient exosomal loading and cellular delivery of a microRNA
Exosomes, membrane-bound nanosized vesicles of biologic origin, are known to contain
various molecules, eg, proteins, lipids, and nucleic acids, which contribute to the exosomes' …
various molecules, eg, proteins, lipids, and nucleic acids, which contribute to the exosomes' …
Advances in colon-targeted nano-drug delivery systems: challenges and solutions
Nano-drug delivery systems (NDDS) for colon-targeted drug delivery are an active area of
research on local diseases affecting the colon, such as ulcerative colitis, Crohn's disease …
research on local diseases affecting the colon, such as ulcerative colitis, Crohn's disease …
Current advances in multifunctional nanocarriers based on marine polysaccharides for colon delivery of food polyphenols
S Tie, M Tan - Journal of Agricultural and Food Chemistry, 2022 - ACS Publications
Inflammatory bowel disease (IBD) has been considered as a chronic disease that is difficult
to cure and needs lifelong treatment. Marine polysaccharides with good biocompatibility and …
to cure and needs lifelong treatment. Marine polysaccharides with good biocompatibility and …
Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease
D Li, M Yang, H Xu, M Zhu, Y Zhang, C Tian… - Journal of Materials …, 2022 - pubs.rsc.org
As a group of chronic and idiopathic gastrointestinal (GI) disorders, inflammatory bowel
disease (IBD) is characterized by recurrent intestinal mucosal inflammation. Oral …
disease (IBD) is characterized by recurrent intestinal mucosal inflammation. Oral …