The PI3K-AKT-mTOR pathway and prostate cancer: at the crossroads of AR, MAPK, and WNT signaling
BY Shorning, MS Dass, MJ Smalley… - International journal of …, 2020 - mdpi.com
Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …
Biochemical and cellular properties of insulin receptor signalling
The mechanism of insulin action is a central theme in biology and medicine. In addition to
the rather rare condition of insulin deficiency caused by autoimmune destruction of …
the rather rare condition of insulin deficiency caused by autoimmune destruction of …
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
The Ras-extracellular signal-regulated kinase (Ras-ERK) and phosphatidylinositol 3-kinase-
mammalian target of rapamycin (PI3K-mTOR) signaling pathways are the chief mechanisms …
mammalian target of rapamycin (PI3K-mTOR) signaling pathways are the chief mechanisms …
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
The Sir2 deacetylase modulates organismal life-span in various species. However, the
molecular mechanisms by which Sir2 increases longevity are largely unknown. We show …
molecular mechanisms by which Sir2 increases longevity are largely unknown. We show …
Cellular survival: a play in three Akts
The programmed cell death that occurs as part of normal mammalian development was first
observed nearly a century ago (Collin 1906). It has since been established that …
observed nearly a century ago (Collin 1906). It has since been established that …
Therapeutic strategies targeting FOXO transcription factors
FOXO proteins are transcription factors that are involved in numerous physiological
processes and in various pathological conditions, including cardiovascular disease, cancer …
processes and in various pathological conditions, including cardiovascular disease, cancer …
PTEN: tumor suppressor and metabolic regulator
CY Chen, J Chen, L He, BL Stiles - Frontiers in endocrinology, 2018 - frontiersin.org
Phosphatase and Tensin Homolog deleted on Chromosome 10 (PTEN) is a dual
phosphatase with both protein and lipid phosphatase activities. PTEN was first discovered …
phosphatase with both protein and lipid phosphatase activities. PTEN was first discovered …
[HTML][HTML] Is Alzheimer's disease a type 3 diabetes? A critical appraisal
Recently researchers proposed the term 'Type-3-Diabetes' for Alzheimer's disease (ad)
because of the shared molecular and cellular features among Type-1-Diabetes, Type-2 …
because of the shared molecular and cellular features among Type-1-Diabetes, Type-2 …
Akt signalling in health and disease
I Hers, EE Vincent, JM Tavaré - Cellular signalling, 2011 - Elsevier
Akt (also known as protein kinase B or PKB) comprises three closely related isoforms Akt1,
Akt2 and Akt3 (or PKBα/β/γ respectively). We have a very good understanding of the …
Akt2 and Akt3 (or PKBα/β/γ respectively). We have a very good understanding of the …
Regulation of glucose metabolism from a liver-centric perspective
HS Han, G Kang, JS Kim, BH Choi… - Experimental & molecular …, 2016 - nature.com
Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs
and maintain an individual's health. The liver has a major role in the control of glucose …
and maintain an individual's health. The liver has a major role in the control of glucose …