Background The use of antithrombotic agents, including anticoagulants, antiplatelet agents,
and thrombolytics has increased over the last decade and is expected to continue to rise …

The aims of severe perioperative bleeding management are three-fold. First, preoperative
identification by anamesis and laboratory testing of those patients for whom the …

Background Severe trauma continues to represent a global public health issue and mortality
and morbidity in trauma patients remains substantial. A number of initiatives have aimed to …

Introduction The appropriate strategy for trauma-induced coagulopathy management is
under debate. We report the treatment of major trauma using mainly coagulation factor …

Introduction The understanding of coagulopathies in trauma has increased interest in
thromboelastography (TEG®) and thromboelastometry (ROTEM®), which promptly evaluate …

Plasma utilization has increased over the past two decades, and there is a growing concern
that many plasma transfusions are inappropriate. Plasma transfusion is not without risk, and …

Fibrinogen plays a critical role in achieving and maintaining hemostasis and is fundamental
to effective clot formation. There is increasing awareness of the important role of fibrinogen …

The article offer guidelines for the haematological management of major haemorrhage in
any clinical situation with practical guidance for Clinical Haematologists. Topics discussed …

Perioperative bleeding is a major challenge particularly because of increasing clinical use of
potent antithrombotic drugs. Understanding current concepts of coagulation is important in …

Fluid resuscitation after massive hemorrhage in major surgery and trauma may result in
extensive hemodilution and coagulopathy, which is of a multifactorial nature. Although …