Metabolomics in cancer research and emerging applications in clinical oncology
Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …
Emerging applications of metabolomics in drug discovery and precision medicine
DS Wishart - Nature reviews Drug discovery, 2016 - nature.com
Metabolomics is an emerging'omics' science involving the comprehensive characterization
of metabolites and metabolism in biological systems. Recent advances in metabolomics …
of metabolites and metabolism in biological systems. Recent advances in metabolomics …
The crucial role of multiomic approach in cancer research and clinically relevant outcomes
M Lu, X Zhan - EPMA Journal, 2018 - Springer
Cancer with heavily economic and social burden is the hot point in the field of medical
research. Some remarkable achievements have been made; however, the exact …
research. Some remarkable achievements have been made; however, the exact …
Metabolic adaptations in prostate cancer
M Pujana-Vaquerizo, L Bozal-Basterra… - British Journal of …, 2024 - nature.com
Prostate cancer is one of the most commonly diagnosed cancers in men and is a major
cause of cancer-related deaths worldwide. Among the molecular processes that contribute …
cause of cancer-related deaths worldwide. Among the molecular processes that contribute …
Applications of metabolomics to study cancer metabolism
AK Kaushik, RJ DeBerardinis - … et Biophysica Acta (BBA)-Reviews on …, 2018 - Elsevier
Reprogrammed metabolism supports tumor growth and provides a potential source of
therapeutic targets and disease biomarkers. Mass spectrometry-based metabolomics has …
therapeutic targets and disease biomarkers. Mass spectrometry-based metabolomics has …
[HTML][HTML] Biomarker discovery in human prostate cancer: an update in metabolomics studies
AR Lima, M de Lourdes Bastos, M Carvalho… - Translational …, 2016 - Elsevier
Prostate cancer (PCa) is the most frequently diagnosed cancer and the second leading
cause of cancer death among men in Western countries. Current screening techniques are …
cause of cancer death among men in Western countries. Current screening techniques are …
[HTML][HTML] The importance of DNA methylation in prostate cancer development
After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools
available to interrogate it, we consider the literature surrounding DNA methylation as …
available to interrogate it, we consider the literature surrounding DNA methylation as …
Comprehensive metabolomic analysis identifies key biomarkers and modulators of immunotherapy response in NSCLC patients
SH Lee, S Kim, J Lee, Y Kim, Y Joo, J Heo, H Lee… - Drug Resistance …, 2024 - Elsevier
Although immune checkpoint inhibitors (ICIs) have revolutionized immuno-oncology with
effective clinical responses, only 30 to 40% of patients respond to ICIs, highlighting the need …
effective clinical responses, only 30 to 40% of patients respond to ICIs, highlighting the need …
Sensors for diagnosis of prostate cancer: Looking beyond the prostate specific antigen
Prostate cancer represents one of the most common forms of cancer affecting men across
the globe. Due to late diagnosis of this disease, the mortality of this condition is very high …
the globe. Due to late diagnosis of this disease, the mortality of this condition is very high …
c-Myc antagonises the transcriptional activity of the androgen receptor in prostate cancer affecting key gene networks
Prostate cancer (PCa) is the most common non-cutaneous cancer in men. The androgen
receptor (AR), a ligand-activated transcription factor, constitutes the main drug target for …
receptor (AR), a ligand-activated transcription factor, constitutes the main drug target for …