FUS and TDP-43 phases in health and disease
The distinct prion-like domains (PrLDs) of FUS and TDP-43, modulate phase transitions that
result in condensates with a range of material states. These assemblies are implicated in …
result in condensates with a range of material states. These assemblies are implicated in …
Protein assembly systems in natural and synthetic biology
The traditional view of protein aggregation as being strictly disease-related has been
challenged by many examples of cellular aggregates that regulate beneficial biological …
challenged by many examples of cellular aggregates that regulate beneficial biological …
Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma
FUS and EWSR1 are RNA-binding proteins with prion-like domains (PrLDs) that aggregate
in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The FUS and …
in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The FUS and …
The hunt for ancient prions: archaeal prion-like domains form amyloid-based epigenetic elements
Prions, proteins that can convert between structurally and functionally distinct states and
serve as non-Mendelian mechanisms of inheritance, were initially discovered and only …
serve as non-Mendelian mechanisms of inheritance, were initially discovered and only …
It pays to be in phase
AK Itakura, RA Futia, DF Jarosz - Biochemistry, 2018 - ACS Publications
To survive, organisms must orchestrate competing biochemical and regulatory processes in
time and space. Recent work has suggested that the underlying chemical properties of some …
time and space. Recent work has suggested that the underlying chemical properties of some …
Molecular origins of complex heritability in natural genotype-to-phenotype relationships
The statistical complexity of heredity has long been evident, but its molecular origins remain
elusive. To investigate, we charted 90 comprehensive genotype-to-phenotype maps in a …
elusive. To investigate, we charted 90 comprehensive genotype-to-phenotype maps in a …
Measuring prion propagation in single bacteria elucidates a mechanism of loss
K Jager, MT Orozco-Hidalgo… - Proceedings of the …, 2023 - National Acad Sciences
Prions are self-propagating protein aggregates formed by specific proteins that can adopt
alternative folds. Prions were discovered as the cause of the fatal transmissible spongiform …
alternative folds. Prions were discovered as the cause of the fatal transmissible spongiform …
The Celiac‐Disease Superantigen Oligomerizes and Increases Permeability in an Enterocyte Cell Model
Celiac disease (CeD) is an autoimmune disorder triggered by gluten proteins, affecting
approximately 1% of the global population. The 33‐mer deamidated gliadin peptide (DGP) …
approximately 1% of the global population. The 33‐mer deamidated gliadin peptide (DGP) …
IDPs and IDRs in biomolecular condensates
AS Holehouse - Intrinsically disordered proteins, 2019 - Elsevier
Over the last decade, there has been considerable interest in the role of intrinsically
disordered proteins and protein regions in the formation of nonstoichiometric assemblies …
disordered proteins and protein regions in the formation of nonstoichiometric assemblies …
What has a century of quantitative genetics taught us about nature's genetic tool kit?
The complexity of heredity has been appreciated for decades: Many traits are controlled not
by a single genetic locus but instead by polymorphisms throughout the genome. The …
by a single genetic locus but instead by polymorphisms throughout the genome. The …