The functional meaning of 5′ UTR in protein-coding genes

N Ryczek, A Łyś, I Makałowska - International journal of molecular …, 2023 - mdpi.com
As it is well known, messenger RNA has many regulatory regions along its sequence length.
One of them is the 5′ untranslated region (5'UTR), which itself contains many regulatory …

Mitochondrial dysfunction and Parkinson's disease: pathogenesis and therapeutic strategies

S Moradi Vastegani, A Nasrolahi, S Ghaderi… - Neurochemical …, 2023 - Springer
Parkinson's disease (PD) is a common age-related neurodegenerative disorder whose
pathogenesis is not completely understood. Mitochondrial dysfunction and increased …

The interplay of signaling pathways and miRNAs in the pathogenesis and targeted therapy of esophageal cancer

AS Doghish, AA El-Husseiny… - … -Research and Practice, 2023 - Elsevier
Globally, esophageal cancer (EC) is the 6th leading cause of cancer-related deaths and the
second deadliest gastrointestinal cancer. Multiple genetic and epigenetic factors, such as …

miRNAs orchestration of gallbladder cancer–particular emphasis on diagnosis, progression and drug resistance

RK Shahin, MA Elkady, AI Abulsoud… - … -Research and Practice, 2023 - Elsevier
Gallbladder cancer (GBC) is characterized by a highly invasive nature and a poor prognosis,
with adenocarcinoma being the main histological subtype. According to statistical data …

The potential role of miRNAs in the pathogenesis of cardiovascular diseases–a focus on signaling pathways interplay

EG Khidr, AI Abulsoud, AA Doghish… - … -Research and Practice, 2023 - Elsevier
For the past two decades since their discovery, scientists have linked microRNAs (miRNAs)
to posttranscriptional regulation of gene expression in critical cardiac physiological and …

Unraveling the role of miRNAs in the diagnosis, progression, and therapeutic intervention of Alzheimer's disease

NM Abdelmaksoud, AAM Sallam, AI Abulsoud… - … -Research and Practice, 2024 - Elsevier
Alzheimer's disease (AD) is a multifaceted, advancing neurodegenerative illness that is
responsible for most cases of neurological impairment and dementia in the aged population …

miRNAs as potential game-changers in retinoblastoma: Future clinical and medicinal uses

AS Doghish, HAM Moustafa, MS Elballal… - … -Research and Practice, 2023 - Elsevier
Retinoblastoma (RB) is a rare tumor in children, but it is the most common primitive
intraocular malignancy in childhood age, especially those below three years old. The RB …

miRNAs orchestration of salivary gland cancer-Particular emphasis on diagnosis, progression, and drug resistance

AA El-Husseiny, NM Abdelmaksoud… - … -Research and Practice, 2023 - Elsevier
Cancer of the salivary glands is one of the five major types of head and neck cancer. Due to
radioresistance and a strong propensity for metastasis, the survival rate for nonresectable …

Melodic maestros: unraveling the role of miRNAs in the diagnosis, progression, and drug resistance of malignant pleural mesothelioma

MA Abd-Elmawla, SSA Mageed… - … -Research and Practice, 2023 - Elsevier
Malignant pleural mesothelioma (MPM) is a highly lethal form of pleural cancer
characterized by a scarcity of effective therapeutic interventions, resulting in unfavorable …

Plasma miRNA profile at COVID-19 onset predicts severity status and mortality

A Fernández-Pato, A Virseda-Berdices… - Emerging microbes & …, 2022 - Taylor & Francis
Background MicroRNAs (miRNAs) have a crucial role in regulating immune response
against infectious diseases, showing changes early in disease onset and before the …