HDL and reverse cholesterol transport: Basic mechanisms and their roles in vascular health and disease

M Ouimet, TJ Barrett, EA Fisher - Circulation research, 2019‏ - ahajournals.org
Cardiovascular disease, with atherosclerosis as the major underlying factor, remains the
leading cause of death worldwide. It is well established that cholesterol ester-enriched foam …

[HTML][HTML] Metazoan micrornas

DP Bartel - Cell, 2018‏ - cell.com
MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

SREBP-regulated lipid metabolism: convergent physiology—divergent pathophysiology

H Shimano, R Sato - Nature Reviews Endocrinology, 2017‏ - nature.com
Cellular lipid metabolism and homeostasis are controlled by sterol regulatory-element
binding proteins (SREBPs). In addition to performing canonical functions in the …

Transcriptional and epigenomic regulation of adipogenesis

JE Lee, H Schmidt, B Lai, K Ge - Molecular and cellular biology, 2019‏ - Taylor & Francis
Understanding adipogenesis, the process of adipocyte development, may provide new ways
to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated …

MicroRNA regulation of atherosclerosis

MW Feinberg, KJ Moore - Circulation research, 2016‏ - ahajournals.org
Atherosclerosis and its attendant clinical complications, such as myocardial infarction,
stroke, and peripheral artery disease, are the leading cause of morbidity and mortality in …

MicroRNAs in cardiovascular disease

T Barwari, A Joshi, M Mayr - Journal of the American College of Cardiology, 2016‏ - jacc.org
Micro-ribonucleic acids (miRNAs) are in the spotlight as post-transcriptional regulators of
gene expression. More than 1,000 miRNAs are encoded in the human genome. In this …

Regulation of long-chain polyunsaturated fatty acid biosynthesis in teleost fish

D **e, C Chen, Y Dong, C You, S Wang… - Progress in Lipid …, 2021‏ - Elsevier
Abstract Omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA, C 20-24),
including eicosapentaenoic acid (EPA, 20: 5n-3) and docosahexaenoic acid (DHA, 22: 6n …

[HTML][HTML] The mucosal immune system of teleost fish

I Salinas - Biology, 2015‏ - mdpi.com
Teleost fish possess an adaptive immune system associated with each of their mucosal
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …

microRNA-33 controls hunger signaling in hypothalamic AgRP neurons

NL Price, P Fernández-Tussy, L Varela… - Nature …, 2024‏ - nature.com
AgRP neurons drive hunger, and excessive nutrient intake is the primary driver of obesity
and associated metabolic disorders. While many factors impacting central regulation of …

miRNAs and NAFLD: from pathophysiology to therapy

M Gjorgjieva, C Sobolewski, D Dolicka, MC de Sousa… - Gut, 2019‏ - gut.bmj.com
Non-alcoholic fatty liver disease (NAFLD) is associated with a thorough reprogramming of
hepatic metabolism. Epigenetic mechanisms, in particular those associated with …