Neutrophil phenotypes and functions in cancer: A consensus statement

DF Quail, B Amulic, M Aziz, BJ Barnes… - Journal of Experimental …, 2022 - rupress.org
Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

Neutrophil diversity and plasticity in tumour progression and therapy

S Jaillon, A Ponzetta, D Di Mitri, A Santoni… - Nature Reviews …, 2020 - nature.com
Neutrophils play a key role in defence against infection and in the activation and regulation
of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have …

T cell subsets and functions in atherosclerosis

R Saigusa, H Winkels, K Ley - Nature Reviews Cardiology, 2020 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …

Neutrophils as emerging therapeutic targets

T Németh, M Sperandio, A Mócsai - Nature reviews Drug discovery, 2020 - nature.com
Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …

The neutrophil's role during health and disease

PX Liew, P Kubes - Physiological reviews, 2019 - journals.physiology.org
Neutrophils have always been considered as uncomplicated front-line troopers of the innate
immune system equipped with limited proinflammatory duties. Yet recently, the role of the …

Neutrophils in physiology and pathology

A Aroca-Crevillén, T Vicanolo, S Ovadia… - Annual Review of …, 2024 - annualreviews.org
Infections, cardiovascular disease, and cancer are major causes of disease and death
worldwide. Neutrophils are inescapably associated with each of these health concerns, by …

Neutrophils at the crossroads of innate and adaptive immunity

C Rosales - Journal of Leucocyte Biology, 2020 - academic.oup.com
Neutrophils are the most abundant leukocytes in blood. From the circulation, they are quickly
mobilized to sites of inflammation and/or infection. At the affected tissues, neutrophils display …

[HTML][HTML] Neutrophil: a cell with many roles in inflammation or several cell types?

C Rosales - Frontiers in physiology, 2018 - frontiersin.org
Neutrophils are the most abundant leukocytes in the circulation, and have been regarded as
first line of defense in the innate arm of the immune system. They capture and destroy …

The neutrophil life cycle

A Hidalgo, ER Chilvers, C Summers… - Trends in …, 2019 - cell.com
Neutrophils are recognized as an essential part of the innate immune response, but an
active debate still exists regarding the life cycle of these cells. Neutrophils first differentiate in …

Neutrophils: New insights and open questions

K Ley, HM Hoffman, P Kubes, MA Cassatella… - Science …, 2018 - science.org
Neutrophils are the first line of defense against bacteria and fungi and help combat parasites
and viruses. They are necessary for mammalian life, and their failure to recover after …