In recent years, brain diseases have seriously threatened human health due to their high
morbidity and mortality. Achieving efficient drug delivery to provide satisfactory therapeutic …

Ischemic stroke is a vascular central nervous system (CNS) disease that leads a disability
and death. Thrombolysis and neuroprotection are the primary treatment strategies of …

Ischemic stroke is an acute and serious cerebral vascular disease, which greatly affects
people's health and brings huge economic burden to society. Microglia, as important innate …

Nanoparticle-based therapy has gained much attention in the pharmaceutical industry.
Fucoidan is a sulfated polysaccharide naturally derived from marine brown algae and is …

Cardiovascular and cerebrovascular diseases (CCVDs) describe abnormal vascular system
conditions affecting the brain and heart. Among these, ischemic heart disease and ischemic …

Nonradiative therapies focusing on converting energy from light into heat (photothermal
therapy, PTT) have been widely studied for the treatment of cancers. In the last years …

Currently, about 40% of approved drugs and nearly 90% of drug candidates are poorly
water-soluble drugs. Low solubility reduces the likelihood that these drugs can be effectively …

Limited therapeutic options are available to effectively preventing atherosclerosis.
Inflammatory endothelial cells, foamy macrophages, and high protease levels contribute to …

Due to the mortality associated with thrombosis and its high recurrence rate, there is a need
to investigate antithrombotic approaches. Noninvasive site-specific thrombolysis is a current …

Acute thrombosis and its complications are leading global causes of disability and death.
Existing thrombolytic drugs, such as alteplase and urokinase (UK), carry a significant …