Assessing and mitigating batch effects in large-scale omics studies

Y Yu, Y Mai, Y Zheng, L Shi - Genome Biology, 2024 - Springer
Batch effects in omics data are notoriously common technical variations unrelated to study
objectives, and may result in misleading outcomes if uncorrected, or hinder biomedical …

The utilization of formalin fixed‐paraffin‐embedded specimens in high throughput genomic studies

P Zhang, BD Lehmann, Y Shyr… - International journal of …, 2017 - Wiley Online Library
High throughput genomic assays empower us to study the entire human genome in short
time with reasonable cost. Formalin fixed‐paraffin‐embedded (FFPE) tissue processing …

Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression

KH Lim, Z Han, HY Jeon, J Kach, E **g… - Nature …, 2020 - nature.com
While most monogenic diseases are caused by loss or reduction of protein function, the
need for technologies that can selectively increase levels of protein in native tissues …

DC ENaC-dependent inflammasome activation contributes to salt-sensitive hypertension

A Pitzer, F Elijovich, CL Laffer, LA Ertuglu… - Circulation …, 2022 - ahajournals.org
Background: Salt sensitivity of blood pressure is an independent predictor of cardiovascular
morbidity and mortality. The exact mechanism by which salt intake increases blood pressure …

Detection of ac4C in human mRNA is preserved upon data reassessment

H Beiki, D Sturgill, D Arango, S Relier, S Schiffers… - Molecular cell, 2024 - cell.com
We recently reported the distribution of N4-acetylcytidine (ac4C) in HeLa mRNA at base
resolution through chemical reduction and the induction of C: T mismatches in sequencing …

β-glucan induces distinct and protective innate immune memory in differentiated macrophages

CL Stothers, KR Burelbach, AM Owen… - The Journal of …, 2021 - journals.aai.org
Bacterial infections are a common and deadly threat to vulnerable patients. Alternative
strategies to fight infection are needed. β-Glucan, an immunomodulator derived from the …

A comprehensive workflow for optimizing RNA-seq data analysis

G Jiang, JY Zheng, SN Ren, W Yin, X ** minimally invasive bone‐specific drug delivery
systems (DDS) to improve fracture healing remains a significant clinical challenge. To …

Strategies for processing and quality control of Illumina genoty** arrays

S Zhao, W **g, DC Samuels, Q Sheng… - Briefings in …, 2018 - academic.oup.com
Illumina genoty** arrays have powered thousands of large-scale genome-wide
association studies over the past decade. Yet, because of the tremendous volume and …