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Assessing and mitigating batch effects in large-scale omics studies
Y Yu, Y Mai, Y Zheng, L Shi - Genome Biology, 2024 - Springer
Batch effects in omics data are notoriously common technical variations unrelated to study
objectives, and may result in misleading outcomes if uncorrected, or hinder biomedical …
objectives, and may result in misleading outcomes if uncorrected, or hinder biomedical …
The utilization of formalin fixed‐paraffin‐embedded specimens in high throughput genomic studies
High throughput genomic assays empower us to study the entire human genome in short
time with reasonable cost. Formalin fixed‐paraffin‐embedded (FFPE) tissue processing …
time with reasonable cost. Formalin fixed‐paraffin‐embedded (FFPE) tissue processing …
Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression
KH Lim, Z Han, HY Jeon, J Kach, E **g… - Nature …, 2020 - nature.com
While most monogenic diseases are caused by loss or reduction of protein function, the
need for technologies that can selectively increase levels of protein in native tissues …
need for technologies that can selectively increase levels of protein in native tissues …
DC ENaC-dependent inflammasome activation contributes to salt-sensitive hypertension
Background: Salt sensitivity of blood pressure is an independent predictor of cardiovascular
morbidity and mortality. The exact mechanism by which salt intake increases blood pressure …
morbidity and mortality. The exact mechanism by which salt intake increases blood pressure …
Detection of ac4C in human mRNA is preserved upon data reassessment
We recently reported the distribution of N4-acetylcytidine (ac4C) in HeLa mRNA at base
resolution through chemical reduction and the induction of C: T mismatches in sequencing …
resolution through chemical reduction and the induction of C: T mismatches in sequencing …
β-glucan induces distinct and protective innate immune memory in differentiated macrophages
CL Stothers, KR Burelbach, AM Owen… - The Journal of …, 2021 - journals.aai.org
Bacterial infections are a common and deadly threat to vulnerable patients. Alternative
strategies to fight infection are needed. β-Glucan, an immunomodulator derived from the …
strategies to fight infection are needed. β-Glucan, an immunomodulator derived from the …
Strategies for processing and quality control of Illumina genoty** arrays
Illumina genoty** arrays have powered thousands of large-scale genome-wide
association studies over the past decade. Yet, because of the tremendous volume and …
association studies over the past decade. Yet, because of the tremendous volume and …