OSTEOCLASTS, which are present only in bone, are multinucleated giant cells with the
capacity to resorb mineralized tissues. During the past decade, several new approaches …

The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone
cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation on …

Gonadal failure induces bone loss while obesity prevents it. This raises the possibility that
bone mass, body weight, and gonadal function are regulated by common pathways. To test …

Although multiple hormones and cytokines regulate various aspects of osteoclast formation,
the final two effectors are osteoprotegerin ligand (OPG‐L)/osteoclast differentiation factor …

Osteoclasts and osteoblasts dictate skeletal mass, structure, and strength via their respective
roles in resorbing and forming bone. Bone remodeling is a spatially coordinated lifelong …

Osteoclasts, the bone-resorbing cells, play a pivotal role in skeletal development and adult
bone remodeling. They also participate in the pathogenesis of various bone disorders …

Osteoporosis is a serious complication of systemic glucocorticoid use. However, while
glucocorticoids increase bone resorption in vitro and in vivo, the mechanism (s) of this effect …

Osteoclasts are terminally differentiated cells derived from hematopoietic stem cells.
However, how their precursor cells diverge from macrophagic lineages is not known. We …

Psoriatic arthritis (PsA) is an inflammatory joint disease characterized by extensive bone
resorption. The mechanisms underlying this matrix loss have not been elucidated. We report …

Receptor activator of nuclear factor (NF-κB) ligand (RANKL), its cellular receptor, receptor
activator of NF-κB (RANK), and the decoy receptor osteoprotegerin (OPG) constitute a novel …