PURPOSE Evidence-based guidelines recommend cascade genetic counseling and testing
for hereditary cancer syndromes, providing relatives the opportunity for early detection and …

Nearly 3% of the population carries genetic variants that lead to conditions that include
hereditary breast and ovarian cancer and Lynch syndrome. These pathogenic variants …

Following the identification in a proband of a germline BRCA1/BRCA2 mutation in hereditary
breast-ovarian cancer (HBOC) or a DNA mismatch repair gene mutation in Lynch syndrome …

PURPOSE A powerful consequence of detecting cancer-associated pathogenic variants is
the ability to test at-risk relatives (ARRs), termed cascade testing. However, historical studies …

Objective This study explored motivators and challenges/barriers to sharing personal
genetic test results (GTR) with family members (FM). Methods Semi-structured, in-depth …

Background Advances in genetics and sequencing technologies are enabling the
identification of more individuals with inherited cancer susceptibility who could benefit from …

Low uptake of genetic services among members of families with hereditary breast and
ovarian cancer (HBOC) suggests limitations of proband-mediated communication of genetic …

Simple Summary This paper presents important information for the implementation of
cascade screening programs for hereditary breast and ovarian cancer (HBOC) and Lynch …

Cascade testing for familial cancer syndromes has historically been difficult to execute. As
part of a facilitated cascade testing pathway, we evaluated barriers to completion of cascade …

Background Cascade genetic testing for hereditary cancer syndromes offers affected
relatives the opportunity to pursue cancer screening and risk‐reducing surgery and thus …