Natural killer cells: a promising immunotherapy for cancer
J Chu, F Gao, M Yan, S Zhao, Z Yan, B Shi… - Journal of translational …, 2022 - Springer
As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have
recently gained attention as an important type of innate immune regulatory cell. NK cells can …
recently gained attention as an important type of innate immune regulatory cell. NK cells can …
The role of natural killer cells in autoimmune diseases
Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …
lymphoid progenitors, were discovered in early 1970's. They are members of innate …
NK cells recognize and kill human glioblastoma cells with stem cell-like properties
In this study, cancer cells were isolated from tumor specimens of nine glioblastoma patients.
Glioblastoma cells, cultured under suitable culture conditions, displayed markers typical of …
Glioblastoma cells, cultured under suitable culture conditions, displayed markers typical of …
[HTML][HTML] Human iPSC-derived natural killer cells engineered with chimeric antigen receptors enhance anti-tumor activity
Chimeric antigen receptors (CARs) significantly enhance the anti-tumor activity of immune
effector cells. Although most studies have evaluated CAR expression in T cells, here we …
effector cells. Although most studies have evaluated CAR expression in T cells, here we …
The natural cytotoxicity receptors in health and disease
The Natural Cytotoxicity Receptors (NCRs), NKp46, NKp44, and NKp30, were some of the
first human activating Natural Killer (NK) cell receptors involved in the non-MHC-restricted …
first human activating Natural Killer (NK) cell receptors involved in the non-MHC-restricted …
Recent advances in targeting CD8 T-cell immunity for more effective cancer immunotherapy
A Durgeau, Y Virk, S Corgnac… - Frontiers in …, 2018 - frontiersin.org
Recent advances in cancer treatment have emerged from new immunotherapies targeting T-
cell inhibitory receptors, including cytotoxic T-lymphocyte associated antigen (CTLA)-4 and …
cell inhibitory receptors, including cytotoxic T-lymphocyte associated antigen (CTLA)-4 and …
Regulation of ligands for the NKG2D activating receptor
NKG2D is an activating receptor expressed by all NK cells and subsets of T cells. It serves
as a major recognition receptor for detection and elimination of transformed and infected …
as a major recognition receptor for detection and elimination of transformed and infected …
NKG2D and its ligands:“one for all, all for one”
The activating receptor NKG2D is peculiar in its capability to bind to numerous and highly
diversified MHC class I-like self-molecules. These ligands are poorly expressed on normal …
diversified MHC class I-like self-molecules. These ligands are poorly expressed on normal …
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity
L Petukhova, M Duvic, M Hordinsky, D Norris, V Price… - Nature, 2010 - nature.com
Alopecia areata (AA) is among the most highly prevalent human autoimmune diseases,
leading to disfiguring hair loss due to the collapse of immune privilege of the hair follicle and …
leading to disfiguring hair loss due to the collapse of immune privilege of the hair follicle and …
Genome of the Chinese tree shrew
Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in
animals used as experimental models in biomedical research. Currently, there are …
animals used as experimental models in biomedical research. Currently, there are …