Neuroinflammation, particularly in the dorsolateral prefrontal cortex, is well-established in a
subset of people with schizophrenia, with significant increases in inflammatory markers …

Hepatic cirrhosis and hepatocellular carcinoma (HCC) are the most common causes of
death in patients with chronic liver disease. Chronic liver injury of virtually any etiology …

NF-κB (nuclear factor-κB) is a collective name for inducible dimeric transcription factors
composed of members of the Rel family of DNA-binding proteins that recognize a common …

The mammalian Rel/NF-κB family of transcription factors, including RelA, c-Rel, RelB, NF-
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central …

The regulation of the transcription factor NF-κB activity occurs at several levels including
controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A …

Abstract The NF-κB/REL family of transcription factors pivotally control the inflammatory and
immune responses, as well as other genetic programmes that are central to cell growth and …

Rel/NF-κB transcription factors are primarily regulated by association with inhibitor IκB
proteins. Thus, in most cells NF-κB exists in the cytoplasm in an inactive complex bound to …

Copyright 2000 Academic PressNF-κB is a heterodimeric transcription factor that plays a key
role in inflammatory and immune responses. In non-stimulated cells, NF-κB dimers are …

The inhibitory protein, IκBα, sequesters the transcription factor, NF-κB, as an inactive
complex in the cytoplasm. The structure of the IκBα ankyrin repeat domain, bound to a …

Loss of articular cartilage through injury or disease presents major clinical challenges also
because cartilage has very poor regenerative capacity, giving rise to the development of …