Triple-negative breast cancer (TNBC) encompasses a heterogeneous group of
fundamentally different diseases with different histologic, genomic, and immunologic …

Cancer has been a leading cause of death for decades. This dismal statistic has increased
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …

Mutations in cancer-associated genes drive tumour outgrowth, but our knowledge of the
timing of driver mutations and subsequent clonal dynamics is limited,–. Here, using whole …

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using
whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL …

Dementia in Alzheimer's disease progresses alongside neurodegeneration,,–, but the
specific events that cause neuronal dysfunction and death remain poorly understood. During …

The APOBEC3 family of cytosine deaminases has been implicated in some of the most
prevalent mutational signatures in cancer,–. However, a causal link between endogenous …

Pancreatic ductal adenocarcinoma (PDAC), already among the deadliest epithelial
malignancies, is rising in both incidence and contribution to overall cancer deaths. Decades …

Colorectal carcinoma (CRC) is a common cause of mortality, but a comprehensive
description of its genomic landscape is lacking,,,,,,–. Here we perform whole-genome …

A fundamental goal in cancer research is to understand the mechanisms of cell
transformation. This is key to develo** more efficient cancer detection methods and …

Checkpoint inhibitors (CPIs) augment adaptive immunity. Systematic pan-tumor analyses
may reveal the relative importance of tumor-cell-intrinsic and microenvironmental features …