Recent progress of solid lipid nanoparticles and nanostructured lipid carriers as ocular drug delivery platforms
Sufficient ocular bioavailability is often considered a challenge by the researchers, due to
the complex structure of the eye and its protective physiological mechanisms. In addition, the …
the complex structure of the eye and its protective physiological mechanisms. In addition, the …
Complex in vitro models positioned for impact to drug testing in pharma: a review
S Kang, EC Chen, H Cifuentes, G Cole, J Graham… - …, 2024 - iopscience.iop.org
Recent years have seen the creation and popularization of various complex in vitro models
(CIVMs), such as organoids and organs-on-chip, as a technology with the potential to …
(CIVMs), such as organoids and organs-on-chip, as a technology with the potential to …
Exploring the impact of morphology on the properties of biodegradable nanoparticles and their diffusion in complex biological medium
R Ridolfo, S Tavakoli, V Junnuthula… - …, 2020 - ACS Publications
Nanoparticle morphology (size, shape, and composition) and surface chemistry are the
determining factors underpinning the efficacy of such materials in therapeutic applications …
determining factors underpinning the efficacy of such materials in therapeutic applications …
[HTML][HTML] Cannabidiol nanoemulsion for eye treatment–Anti-inflammatory, wound healing activity and its bioavailability using in vitro human corneal substitute
O Strnad, J Šuman, T Veverková, A Sukupová… - International Journal of …, 2023 - Elsevier
Cannabidiol (CBD) is the non-psychoactive component of the plant Cannabis sativa (L.) that
has great anti-inflammatory benefits and wound healing effects. However, its high …
has great anti-inflammatory benefits and wound healing effects. However, its high …
The role of mucus in cell-based models used to screen mucosal drug delivery
The increasing interest in develo** tools to predict drug absorption through mucosal
surfaces is fostering the establishment of epithelial cell-based models. Cell-based in vitro …
surfaces is fostering the establishment of epithelial cell-based models. Cell-based in vitro …
Corneal cell therapy: with iPSCs, it is no more a far-sight
K Chakrabarty, R Shetty, A Ghosh - Stem cell research & therapy, 2018 - Springer
Human-induced pluripotent stem cells (hiPSCs) provide a personalized approach to study
conditions and diseases including those of the eye that lack appropriate animal models to …
conditions and diseases including those of the eye that lack appropriate animal models to …
Nanocrystals: Characterization overview, applications in drug delivery, and their toxicity concerns
Nanocrystals (NCs) are the class of solid dosage forms which utilizes the concept of
nanoscience together with crystal nature of drug to achieve advantages in terms of solubility …
nanoscience together with crystal nature of drug to achieve advantages in terms of solubility …
Non-invasive strategies for targeting the posterior segment of eye
The safe and effective treatment of eye diseases has been remained a global myth. Several
advancements have been done and various drug delivery and treatment techniques have …
advancements have been done and various drug delivery and treatment techniques have …
Looking into the eyes—in vitro models for ocular research
K Lieto, R Skopek, A Lewicka, M Stelmasiak… - International Journal of …, 2022 - mdpi.com
Animal research undoubtedly provides scientists with virtually unlimited data but inflicts pain
and suffering on animals. Currently, legislators and scientists alike are promoting alternative …
and suffering on animals. Currently, legislators and scientists alike are promoting alternative …
Quantitative systems pharmacology of the eye: Tools and data for ocular QSP
L Kuepfer, G Fuellen, T Stahnke - CPT: Pharmacometrics & …, 2023 - Wiley Online Library
Good eyesight belongs to the most‐valued attributes of health, and diseases of the eye are a
significant healthcare burden. Case numbers are expected to further increase in the next …
significant healthcare burden. Case numbers are expected to further increase in the next …