Recent progress of solid lipid nanoparticles and nanostructured lipid carriers as ocular drug delivery platforms

V Gugleva, V Andonova - Pharmaceuticals, 2023 - mdpi.com
Sufficient ocular bioavailability is often considered a challenge by the researchers, due to
the complex structure of the eye and its protective physiological mechanisms. In addition, the …

Complex in vitro models positioned for impact to drug testing in pharma: a review

S Kang, EC Chen, H Cifuentes, G Cole, J Graham… - …, 2024 - iopscience.iop.org
Recent years have seen the creation and popularization of various complex in vitro models
(CIVMs), such as organoids and organs-on-chip, as a technology with the potential to …

Exploring the impact of morphology on the properties of biodegradable nanoparticles and their diffusion in complex biological medium

R Ridolfo, S Tavakoli, V Junnuthula… - …, 2020 - ACS Publications
Nanoparticle morphology (size, shape, and composition) and surface chemistry are the
determining factors underpinning the efficacy of such materials in therapeutic applications …

[HTML][HTML] Cannabidiol nanoemulsion for eye treatment–Anti-inflammatory, wound healing activity and its bioavailability using in vitro human corneal substitute

O Strnad, J Šuman, T Veverková, A Sukupová… - International Journal of …, 2023 - Elsevier
Cannabidiol (CBD) is the non-psychoactive component of the plant Cannabis sativa (L.) that
has great anti-inflammatory benefits and wound healing effects. However, its high …

The role of mucus in cell-based models used to screen mucosal drug delivery

A Lechanteur, J das Neves, B Sarmento - Advanced drug delivery reviews, 2018 - Elsevier
The increasing interest in develo** tools to predict drug absorption through mucosal
surfaces is fostering the establishment of epithelial cell-based models. Cell-based in vitro …

Corneal cell therapy: with iPSCs, it is no more a far-sight

K Chakrabarty, R Shetty, A Ghosh - Stem cell research & therapy, 2018 - Springer
Human-induced pluripotent stem cells (hiPSCs) provide a personalized approach to study
conditions and diseases including those of the eye that lack appropriate animal models to …

Nanocrystals: Characterization overview, applications in drug delivery, and their toxicity concerns

MA Jahangir, SS Imam, A Muheem… - Journal of …, 2020 - Springer
Nanocrystals (NCs) are the class of solid dosage forms which utilizes the concept of
nanoscience together with crystal nature of drug to achieve advantages in terms of solubility …

Non-invasive strategies for targeting the posterior segment of eye

A Madni, MA Rahem, N Tahir, M Sarfraz, A Jabar… - International journal of …, 2017 - Elsevier
The safe and effective treatment of eye diseases has been remained a global myth. Several
advancements have been done and various drug delivery and treatment techniques have …

Looking into the eyes—in vitro models for ocular research

K Lieto, R Skopek, A Lewicka, M Stelmasiak… - International Journal of …, 2022 - mdpi.com
Animal research undoubtedly provides scientists with virtually unlimited data but inflicts pain
and suffering on animals. Currently, legislators and scientists alike are promoting alternative …

Quantitative systems pharmacology of the eye: Tools and data for ocular QSP

L Kuepfer, G Fuellen, T Stahnke - CPT: Pharmacometrics & …, 2023 - Wiley Online Library
Good eyesight belongs to the most‐valued attributes of health, and diseases of the eye are a
significant healthcare burden. Case numbers are expected to further increase in the next …