Overview of apoptosis, autophagy, and inflammatory processes in Toxoplasma gondii infected cells

E Ahmadpour, F Babaie, T Kazemi… - Pathogens, 2023 - mdpi.com
Toxoplasma gondii (T. gondii) is an obligate intracellular parasite. During the parasitic
invasion, T. gondii creates a parasitophorous vacuole, which enables the modulation of cell …

Ghrelin: An Emerging Therapy for Heart Failure

N Theodorakis, G Feretzakis, M Kreouzi… - Clinical …, 2025 - Wiley Online Library
Objective Ghrelin is emerging as a promising therapeutic option for heart failure (HF) due to
its potent inotropic, anabolic, and cardioprotective properties. This review aims to critically …

Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1α/AMPK/Sirt1/PGC-1α/UCP2 pathway in a rat model of neonatal HIE

J Huang, W Liu, DM Doycheva, M Gamdzyk… - Free Radical Biology …, 2019 - Elsevier
Neuronal apoptosis induced by oxidative stress is one of the major pathological processes
involved in neurological impairment after hypoxic-ischemic encephalopathy (HIE). Ghrelin …

A high‐fat diet rich in corn oil induces cardiac fibrosis in rats by activating JAK2/STAT3 and subsequent activation of ANG II/TGF‐1β/Smad3 pathway: The role of ROS …

RA Eid, MA Alkhateeb, AF El‐Kott… - Journal of Food …, 2019 - Wiley Online Library
This study compared the effect of low‐fat diet (LFD) and high‐fat diet rich in corn oil (HFD‐
CO) on left ventricular (LV) fibrosis in rats and examined their effect of angiotensin II (ANG II) …

Exendin-4 attenuates remodeling in the remote myocardium of rats after an acute myocardial infarction by activating β-arrestin-2, protein phosphatase 2A, and …

RA Eid, MA Khalil, MA Alkhateeb, SM Eleawa… - … drugs and therapy, 2021 - Springer
Purpose This study tested if the protective anti-remodeling effect of GLP-1 agonist Exendin-4
after an acute myocardial infarction (MI) in rats involves inhibition of the Wnt1/β-catenin …

Exendin-4 ameliorates cardiac remodeling in experimentally induced myocardial infarction in rats by inhibiting PARP1/NF-κB Axis in A SIRT1-dependent mechanism

RA Eid, SA Alharbi, AF El-Kott, SM Eleawa… - Cardiovascular …, 2020 - Springer
Sirt1 is a potent inhibitor of both poly (ADP-ribose) polymerases1 (PARP1) and NF-kB. This
study investigated the cardioprotective effect of exendin-4 on cardiac function and …

Functional and prognostic implications of cardiac magnetic resonance feature tracking-derived remote myocardial strain analyses in patients following acute …

T Lange, T Stiermaier, SJ Backhaus, PC Boom… - Clinical Research in …, 2021 - Springer
Background Cardiac magnetic resonance myocardial feature tracking (CMR-FT)-derived
global strain assessments provide incremental prognostic information in patients following …

“Sibling” battle or harmony: crosstalk between nesfatin-1 and ghrelin

X Chen, J Dong, Q Jiao, X Du, M Bi, H Jiang - Cellular and Molecular Life …, 2022 - Springer
Ghrelin was first identified as an endogenous ligand of the growth hormone secretagogue
receptor (GHSR) in 1999, with the function of stimulating the release of growth hormone …

Gut molecules in cardiometabolic diseases: the mechanisms behind the story

AI Inceu, MA Neag, AE Craciun… - International Journal of …, 2023 - mdpi.com
Atherosclerotic cardiovascular disease is the most common cause of morbidity and mortality
worldwide. Diabetes mellitus increases cardiovascular risk. Heart failure and atrial fibrillation …

Pretreatment of ghrelin protects H9c2 cells against hypoxia/reoxygenation-induced cell death via PI3K/AKT and AMPK pathways

Y Chen, H Wang, Y Zhang, Z Wang… - Artificial Cells …, 2019 - Taylor & Francis
Ghrelin has been widely recognized as a key peptide in the cardiovascular system. This
study detected the potential of ghrelin in MI management and tried to decode one of the …