The rich diversity of secondary metabolites produced by soil bacteria has been appreciated
for over a century, and advances in chemical analysis and genome sequencing continue to …

Covering: 1994 to 2002 The ability to synthesize nonribosomally small bioactive peptides
that find application in modern medicine is widely spread among microorganisms. As broad …

Medicinal Natural Products, Second Edition is a comprehensive guide providing information
on all classes of natural products in medicine. It builds upon fundamental chemical …

Nonribosomal peptides and polyketides are a diverse group of natural products with
complex chemical structures and enormous pharmaceutical potential. They are synthesized …

Transient infection of eukaryotic cells with commensal and extraintestinal pathogenic
Escherichia coli of phylogenetic group B2 blocks mitosis and induces megalocytosis. This …

Cyanobacteria are a prolific source of secondary metabolites, including compounds with
toxic and enzyme-inhibiting activities. Microcystins and nodularins are the end products of a …

Covering: up to September 2009 This review covers the recent literature on the release
mechanisms for polyketides and nonribosomal peptides produced by microorganisms. The …

Antibiotics are precious resources in the fight to combat bacterial infections caused by
pathogenic organisms. Vancomycin is one of the antibiotics of last resort in the treatment of …

Nonribosomal peptide synthetases (NRPSs) catalyze the assembly of a large number of
complex peptide natural products, many of which display therapeutically useful activity. Each …

Isolated during 1950s and 1960s, the group of lipopeptides from Bacillus spp. gather more
than 30 different peptides linked to various fatty acid chains. More than a 100 different …