Epigenomic insights into common human disease pathology

CG Bell - Cellular and Molecular Life Sciences, 2024 - Springer
The epigenome—the chemical modifications and chromatin-related packaging of the
genome—enables the same genetic template to be activated or repressed in different …

Evolution of the mutation spectrum across a mammalian phylogeny

AC Beichman, J Robinson, M Lin… - Molecular Biology …, 2023 - academic.oup.com
Although evolutionary biologists have long theorized that variation in DNA repair efficacy
might explain some of the diversity of lifespan and cancer incidence across species, we …

Accurate inference of population history in the presence of background selection

T Cousins, D Tabin, N Patterson, D Reich… - …, 2024 - pmc.ncbi.nlm.nih.gov
All published methods for learning about demographic history make the simplifying
assumption that the genome evolves neutrally, and do not seek to account for the effects of …

k-mer-based approaches to bridging pangenomics and population genetics

MD Roberts, O Davis, EB Josephs… - arxiv preprint arxiv …, 2024 - arxiv.org
Many commonly studied species now have more than one chromosome-scale genome
assembly, revealing a large amount of genetic diversity previously missed by approaches …