Euglenozoa is a species-rich group of protists, which have extremely diverse lifestyles and a
range of features that distinguish them from other eukaryotes. They are composed of free …

The number of sequenced trypanosomatid genomes has reached a critical point so that they
are now available for almost all genera and subgenera. Based on this, we inferred a …

Cognate tRNAs deliver specific amino acids to translating ribosomes according to the
standard genetic code, and three codons with no cognate tRNAs serve as stop codons …

Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on
health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast …

Chagas disease caused by the parasite Trypanosoma cruzi affects millions of people.
Although its first genome dates from 2005, its complexity hindered a complete assembly and …

AlphaFold2 and RoseTTAfold represent a transformative advance for predicting protein
structure. They are able to make very high-quality predictions given a high-quality alignment …

In this review, we summarize the current data on development of monoxenous
trypanosomatids and phytomonads in various insects. Of these, Diptera and Hemiptera are …

Background Protists of the family Trypanosomatidae (phylum Euglenozoa) have gained
notoriety as parasites affecting humans, domestic animals, and agricultural plants. However …

Transmission of trypanosomatids to their mammalian hosts requires a complex series of
developmental transitions in their insect vectors, including stable attachment to an insect …

This review explores the origins of intracellular parasitism, an intriguing facet of symbiosis,
where one organism harms its host, potentially becoming deadly. We focus on three …