Intracellular transport is fundamental for cellular function, survival and morphogenesis.
Kinesin superfamily proteins (also known as KIFs) are important molecular motors that …

The kinesin, dynein, and myosin superfamily molecular motors have fundamental roles in
neuronal function, plasticity, morphogenesis, and survival by transporting cargos such as …

Axonal transport is essential for neuronal function, and many neurodevelopmental and
neurodegenerative diseases result from mutations in the axonal transport machinery …

The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …

Vesicles, organelles and other intracellular cargo are transported by kinesin and dynein
motors, which move in opposite directions along microtubules. This bidirectional cargo …

Vinca alkaloids have been approved as anticancer drugs for more than 50 years. They have
been classified as cytotoxic chemotherapy drugs that act during cellular mitosis, enabling …

Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move
along the surface of, or destabilize, microtubule filaments. Much progress has been made in …

Intracellular trafficking of cargoes is an essential process to maintain the structure and
function of all mammalian cell types, but especially of neurons because of their extreme …

Here we demonstrate that the dual leucine zipper kinase (DLK) promotes robust
regeneration of peripheral axons after nerve injury in mice. Peripheral axon regeneration is …

Mitochondria play an essential role in ATP generation, calcium buffering and apoptotic
signalling. In neurons, the transport of mitochondria to specific locations where they are …