Calcium cycling and signaling in cardiac myocytes
DM Bers - Annu. Rev. Physiol., 2008 - annualreviews.org
Calcium (Ca) is a universal intracellular second messenger. In muscle, Ca is best known for
its role in contractile activation. However, in recent years the critical role of Ca in other …
its role in contractile activation. However, in recent years the critical role of Ca in other …
Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation–contraction coupling in the heart
Abstract Calcium (Ca2+) is the central second messenger in the translation of electrical
signals into mechanical activity of the heart. This highly coordinated process, termed …
signals into mechanical activity of the heart. This highly coordinated process, termed …
[BOOK][B] Excitation-contraction coupling and cardiac contractile force
D Bers - 2001 - books.google.com
How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …
What are the links between cardiac structure and function? How does our understanding of …
The δC Isoform of CaMKII Is Activated in Cardiac Hypertrophy and Induces Dilated Cardiomyopathy and Heart Failure
Recent studies have demonstrated that transgenic (TG) expression of either
Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) or CaMKIIδB, both of which …
Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) or CaMKIIδB, both of which …
Transgenic CaMKIIδC Overexpression Uniquely Alters Cardiac Myocyte Ca2+ Handling: Reduced SR Ca2+ Load and Activated SR Ca2+ Release
LS Maier, T Zhang, L Chen, J DeSantiago… - Circulation …, 2003 - Am Heart Assoc
Ca2+/calmodulin-dependent protein kinase II (CaMKII) δ is the predominant cardiac isoform,
and the δC splice variant is cytoplasmic. We overexpressed CaMKIIδC in mouse heart and …
and the δC splice variant is cytoplasmic. We overexpressed CaMKIIδC in mouse heart and …
Requirement for Ca2+/calmodulin–dependent kinase II in the transition from pressure overload–induced cardiac hypertrophy to heart failure in mice
H Ling, T Zhang, L Pereira, CK Means… - The Journal of …, 2009 - Am Soc Clin Investig
Ca2+/calmodulin–dependent kinase II (CaMKII) has been implicated in cardiac hypertrophy
and heart failure. We generated mice in which the predominant cardiac isoform, CaMKIIδ …
and heart failure. We generated mice in which the predominant cardiac isoform, CaMKIIδ …
Ca2+ Handling and Sarcoplasmic Reticulum Ca2+ Content in Isolated Failing and Nonfailing Human Myocardium
Disturbed sarcoplasmic reticulum (SR) Ca2+ content may underlie the altered force-
frequency and postrest contractile behavior in failing human myocardium. We used rapid …
frequency and postrest contractile behavior in failing human myocardium. We used rapid …
Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model
TJ Hund, Y Rudy - Circulation, 2004 - Am Heart Assoc
Background—Computational biology is a powerful tool for elucidating arrhythmogenic
mechanisms at the cellular level, where complex interactions between ionic processes …
mechanisms at the cellular level, where complex interactions between ionic processes …
Calcium, calmodulin, and calcium-calmodulin kinase II: heartbeat to heartbeat and beyond
LS Maier and DM Bers. Calcium, Calmodulin, and Calcium-Calmodulin Kinase II: Heartbeat
to Heartbeat and Beyond. Journal of Molecular and Cellular Cardiology (2002) 34, 919–939 …
to Heartbeat and Beyond. Journal of Molecular and Cellular Cardiology (2002) 34, 919–939 …
Ryanodine receptor Ca2+ release channels: does diversity in form equal diversity in function?
JL Sutko, JA Airey - Physiological Reviews, 1996 - journals.physiology.org
Complexities in calcium signaling in eukaryotic cells require diversity in the proteins
involved in generating these signals. In this review, we consider the ryanodine receptor …
involved in generating these signals. In this review, we consider the ryanodine receptor …