Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the …
Apramycin is a structurally unique member of the 2-deoxystreptamine class of
aminoglycoside antibiotics characterized by a monosubstituted 2-deoxystreptamine ring that …
aminoglycoside antibiotics characterized by a monosubstituted 2-deoxystreptamine ring that …
Synthesis, Antibacterial and Antiribosomal Activity of the 3C-Aminoalkyl Modification in the Ribofuranosyl Ring of Apralogs (5-O-Ribofuranosyl Apramycins)
D Lubriks, K Haldimann, SN Hobbie, A Vasella, E Suna… - Antibiotics, 2022 - mdpi.com
The synthesis and antiribosomal and antibacterial activity of both anomers of a novel
apralog, 5-O-(5-amino-3-C-dimethylaminopropyl-D-ribofuranosyl) apramycin, are reported …
apralog, 5-O-(5-amino-3-C-dimethylaminopropyl-D-ribofuranosyl) apramycin, are reported …