The colon mucus layer is organized with an inner colon mucus layer that is impenetrable to
bacteria and an outer mucus layer that is expanded to allow microbiota colonization. A major …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Glycosylation is the most abundant and diverse form of post-translational modification of
proteins that is common to all eukaryotic cells. Enzymatic glycosylation of proteins involves a …

The glycome describes the complete repertoire of glycoconjugates composed of
carbohydrate chains, or glycans, that are covalently linked to lipid or protein molecules …

Protein post-translational modification (PTM) is a covalent process that occurs in proteins
during or after translation through the addition or removal of one or more functional groups …

Generating the barriers that protect our inner surfaces from bacteria and other challenges
requires large glycoproteins called mucins. These come in two types, gel-forming and …

The intestinal mucosal barrier is composed of epithelial cells that are protected by an
overlying host-secreted mucous layer and functions as the first line of defence against …

This review provides insights on the impact of glycosylation in cancer biology and its
influence in the current approaches of targeted cancer therapies in the clinical setting. The …

In this review we discuss mucus, the viscoelastic secretion from goblet or mucous producing
cells that lines the epithelial surfaces of all organs exposed to the external world. Mucus is a …

Inflammatory bowel disease (IBD) affects 6.8 million people globally. A variety of factors
have been implicated in IBD pathogenesis, including host genetics, immune dysregulation …