Ras homology (RHO) GTPases are signalling proteins that have crucial roles in triggering
multiple immune functions. Through their interactions with a broad range of effectors and …

Recent research has led to novel findings in inflammasome biology and genetics that
altered the diagnosis and management of patients with autoinflammatory syndromes caused …

Fasting triggers diverse physiological adaptations including increases in circulating fatty
acids and mitochondrial respiration to facilitate organismal survival. The mechanisms driving …

A growing number of monogenic immune-mediated diseases have been related to genes
involved in pathways of actin cytoskeleton remodeling. Increasing evidences associate …

To the Editor: Autoinflammatory syndromes are caused by dysregulation of the innate
immune system, often affecting the inflammasome and other pathogen recognition pathways …

Rac1 is a small RhoGTPase switch that orchestrates actin branching in space and time and
protrusion/retraction cycles of the lamellipodia at the cell front during mesenchymal …

Rho-GTPases control a variety of cellular functions mainly by regulating microtubule and
actin dynamics, affecting the cytoskeleton, and are important regulators of the structural …

Polarized Rac1 signaling is a hallmark of many cellular functions, including cell adhesion,
motility, and cell division. The two steps of Rac1 activation are its translocation to the plasma …

FIG 1. A, Pustular psoriasiform lesions and severe psoriasiform erythrodema. B, Pedigree. C,
Structure of Cdc42, highlighting the mutated R186 (red). D, Staining of the Golgi apparatus …

Abstract Membrane localization of Rho GTPases is essential for their biological functions
and is dictated in part by a series of posttranslational modifications at a carboxyl-terminal …