Natural products and their structural analogues have historically made a major contribution
to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural …

Mankind has recognized the value of land plants as renewable sources of food, medicine,
and materials for millennia. Throughout human history, agricultural methods were …

Advances in omics technologies now permit the generation of highly contiguous genome
assemblies, detection of transcripts and metabolites at the level of single cells and high …

Monoterpenoid indole alkaloids (MIAs) are among the most diverse specialized metabolites
in plants and are of great pharmaceutical importance. We leveraged single-cell …

Medicinal plants have historically proven their value as a source of molecules with
therapeutic potential, and nowadays still represent an important pool for the identification of …

Few complete pathways have been established for the biosynthesis of medicinal
compounds from plants. Accordingly, many plant-derived therapeutics are isolated directly …

Current approaches for the production of high-value compounds in microorganisms mostly
use the cytosol as a general reaction vessel. However, competing pathways and metabolic …

Alkaloids from plants are characterised by structural diversity and bioactivity, and maintain a
privileged position in both modern and traditional medicines. In recent years, there have …

Catharanthine can be coupled with vindoline to synthesize vinblastine and vincristine, which
have been used clinically as potent anticancer drugs. However, the structural complexity …

Camptothecin and its derivatives are widely used for treating malignant tumors. Previous
studies revealed only a limited number of candidate genes for camptothecin biosynthesis in …