Over the past decade, protein–protein interactions (PPIs) have gone from being neglected
as 'undruggable'to being considered attractive targets for the development of therapeutics …

Abstract Secondary C (sp3)− H arylations were accomplished by palladium catalysis with
triazoles as peptide bond isosteres. The unique power of this approach is highlighted by the …

Decorating biomolecular building blocks, such as amino acids, to afford desired and
tuneable photophysical/biophysical properties would allow chemical biologists to use them …

Aggregation of amyloid peptides results in severe neurodegenerative diseases. While the
fibril structures of Aβ 40 and Aβ 42 have been described recently, resolution of the …

Novel fluorinated foldamers based on aminomethyl‐1, 4‐triazolyl‐difluoroacetic acid (1, 4‐
Tz− CF2) units were synthesized and their conformational behaviour was studied by NMR …

Breast cancer is the second most frequent cancer among women. Out of various subtypes,
triple‐negative breast cancers (TNBCs) account for 15% of breast cancers and exhibit more …

An environmentally friendly solution-phase synthesis has been developed for producing
trans-5-aminopenta-3-enoic acid (trans-δ-Apa), along with several Nα-and C-terminal …

The research in the field of design and synthesis of unnatural amino acids is growing at a
fast space for the increasing demand of proteins of potential therapeutics and many other …

β-Strands are formed by extended linear peptide chains that are usually paired to form β-
sheet structure through interstrand hydrogen bonding. Linking a structured organic molecule …

The N-difluoromethyl triazolo-β-aza-ε-amino acid present in the core of peptides led to
constrained conformations due to CH–F and NH–F interactions. Pseudotetrapeptides were …