Intron retention (IR) occurs when a complete and unspliced intron remains in mature mRNA.
An increasing body of literature has demonstrated a major role for IR in numerous biological …

C9ORF72 hexanucleotide repeat expansion is the most common genetic cause of both
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). One pathogenic …

Human brain organoids are self-organizing three-dimensional structures that emerge from
human pluripotent stem cells and mimic aspects of the cellular composition and functionality …

In light of the numerous studies identifying post-transcriptional regulators on the surface of
the endoplasmic reticulum (ER), we asked whether there are factors that regulate …

Programmed cell death 4 (PDCD4) protein is a tumor suppressor that inhibits translation
through the mTOR-dependent initiation factor EIF4A, but its functional role and mRNA …

Accumulation of secondary metabolites in the young shoots of tea plants is developmentally
modulated, especially flavonoids. Here, we investigate the developmental regulation …

Emerging evidence places small proteins (≤ 50 amino acids) more centrally in
physiological processes. Yet, their functional identification and the systematic genome …

An excessive high-fat/energy diet is a major cause of obesity and linked complications, such
as non-alcoholic fatty liver disease (NAFLD). Betaine has been shown to effectively improve …

The daily organisation of most mammalian cellular functions is attributed to circadian
regulation of clock‐controlled protein expression, driven by daily cycles of …

Conventional preparation methods of plant ribosomes fail to resolve non-translating
chloroplast or cytoplasmic ribosome subunits from translating fractions. We established …