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Emerging concepts in the science of vaccine adjuvants
Adjuvants are vaccine components that enhance the magnitude, breadth and durability of
the immune response. Following its introduction in the 1920s, alum remained the only …
the immune response. Following its introduction in the 1920s, alum remained the only …
New-age vaccine adjuvants, their development, and future perspective
In the present scenario, immunization is of utmost importance as it keeps us safe and
protects us from infectious agents. Despite the great success in the field of vaccinology …
protects us from infectious agents. Despite the great success in the field of vaccinology …
[HTML][HTML] The NLRP3 inflammasome: an overview of mechanisms of activation and regulation
The NLRP3 inflammasome is a critical component of the innate immune system that
mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in …
mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in …
The COVID-19 vaccine race: challenges and opportunities in vaccine formulation
In the race for a safe and effective vaccine against coronavirus disease (COVID)-19,
pharmaceutical formulation science plays a critical role throughout the development …
pharmaceutical formulation science plays a critical role throughout the development …
[HTML][HTML] Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) in 2023
In 2011, a syndrome entitled ASIA (Autoimmune/inflammatory Syndrome Induced by
Adjuvants; Shoenfeld's syndrome) was first described. ASIA aimed to organize under a …
Adjuvants; Shoenfeld's syndrome) was first described. ASIA aimed to organize under a …
Targeting the NLRP3 inflammasome in inflammatory diseases
MSJ Mangan, EJ Olhava, WR Roush… - Nature reviews Drug …, 2018 - nature.com
Danger signals are a hallmark of many common inflammatory diseases, and these stimuli
can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR …
can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR …
Structure and function of the immune system in the spleen
The spleen is the largest secondary lymphoid organ in the body and, as such, hosts a wide
range of immunologic functions alongside its roles in hematopoiesis and red blood cell …
range of immunologic functions alongside its roles in hematopoiesis and red blood cell …
Manganese salts function as potent adjuvants
Aluminum-containing adjuvants have been used for nearly 100 years to enhance immune
responses in billions of doses of vaccines. To date, only a few adjuvants have been …
responses in billions of doses of vaccines. To date, only a few adjuvants have been …
CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes
Dendritic cells (DCs) and monocytes capture, transport, and present antigen to cognate T
cells in the draining lymph nodes (LNs) in a CCR7-dependent manner. Since only migratory …
cells in the draining lymph nodes (LNs) in a CCR7-dependent manner. Since only migratory …
Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want
Aluminum-containing adjuvants have been used for over 90 years to enhance the immune
response to vaccines. Recent work has significantly advanced our understanding of the …
response to vaccines. Recent work has significantly advanced our understanding of the …