Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

Decades of research have identified genetic and environmental factors involved in age-
related neurodegenerative diseases and, to a lesser extent, neuropsychiatric disorders …

Background: Little is known about the prevalence of cellular senescence among immune
cells (ie, immune cells expressing senescence markers, iSCs) nor is there a gold-standard …

Objective Oxidative DNA damage has been associated with the pathophysiology of bipolar
disorder (BD) as one of the common pathways between increased medical comorbidity and …

The therapeutic use of many pharmaceuticals, including small molecules and biological
therapies, has been associated with the onset of psychiatric and psychological adverse …

Previous evidence suggests elevated levels of oxidatively-induced DNA damage,
particularly 8-hydroxy-2'-deoxyguanosine (8-OH-dG), and abnormalities in the repair of 8 …

Mood disorders, including major depressive disorder and bipolar disorder, are highly
prevalent and stand among the leading causes of disability. Despite the largely elusive …

Background Depression weakens antitumor immunity, yet the underlying mechanisms
linking depression and tumor growth remain unclear. This study examines the influence of …

Abstract Introduction: Bipolar disorder (BD), a mood disorder with recurrent affective
episodes and a strong genetic basis is frequently associated with significant comorbidities …

Previous evidence suggests elevated levels of oxidative DNA damage, particularly 8-
hydroxy-2'-deoxyguanosine (8-OH-dG), and abnormalities in the repair of 8-OH-dG by the …