Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors
R Edmondson, JJ Broglie, AF Adcock… - Assay and drug …, 2014 - liebertpub.com
Abstract Three-dimensional (3D) cell culture systems have gained increasing interest in
drug discovery and tissue engineering due to their evident advantages in providing more …
drug discovery and tissue engineering due to their evident advantages in providing more …
Hydrogels as artificial matrices for cell seeding in microfluidic devices
Hydrogel-based artificial scaffolds play a vital role in shifting in vitro models from two-
dimensional (2D) cell culture to three-dimensional (3D) cell culture. Microfluidic 3D cell …
dimensional (2D) cell culture to three-dimensional (3D) cell culture. Microfluidic 3D cell …
Systematic optimization of visible light-induced crosslinking conditions of gelatin methacryloyl (GelMA)
Gelatin methacryloyl (GelMA) is one of the most widely used photo-crosslinkable
biopolymers in tissue engineering. In in presence of an appropriate photoinitiator, the light …
biopolymers in tissue engineering. In in presence of an appropriate photoinitiator, the light …
Modeling pancreatic cancer with organoids
Pancreatic ductal adenocarcinoma (PDA) is a highly lethal malignancy for which new
treatment and diagnostic approaches are urgently needed. For such breakthroughs to be …
treatment and diagnostic approaches are urgently needed. For such breakthroughs to be …
[HTML][HTML] Three-dimensional cell culture systems as an in vitro platform for cancer and stem cell modeling
N Chaicharoenaudomrung, P Kunhorm… - World journal of stem …, 2019 - ncbi.nlm.nih.gov
Abstract Three-dimensional (3D) culture systems are becoming increasingly popular due to
their ability to mimic tissue-like structures more effectively than the monolayer cultures. In …
their ability to mimic tissue-like structures more effectively than the monolayer cultures. In …
3D cell cultures: Evolution of an ancient tool for new applications
A Cacciamali, R Villa, S Dotti - Frontiers in Physiology, 2022 - frontiersin.org
Recently, research is undergoing a drastic change in the application of the animal model as
a unique investigation strategy, considering an alternative approach for the development of …
a unique investigation strategy, considering an alternative approach for the development of …
[HTML][HTML] In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models
SY Lee, IS Koo, HJ Hwang, DW Lee - SLAS Discovery, 2023 - Elsevier
Abstract Three-dimensional (3D) cell culture technology has been steadily studied since the
1990's due to its superior biocompatibility compared to the conventional two-dimensional …
1990's due to its superior biocompatibility compared to the conventional two-dimensional …
Advanced cell culture platforms: a growing quest for emulating natural tissues
In the body, cells inhabit within a complex three-dimensional (3D) extracellular matrix that
provides physical and chemical signals to regulate the cell fate. Cultured cells in Petri dishes …
provides physical and chemical signals to regulate the cell fate. Cultured cells in Petri dishes …
Vascularization strategies in 3D cell culture models: from scaffold-free models to 3D bioprinting
SG Anthon, KP Valente - International journal of molecular sciences, 2022 - mdpi.com
The discrepancies between the findings in preclinical studies, and in vivo testing and clinical
trials have resulted in the gradual decline in drug approval rates over the past decades …
trials have resulted in the gradual decline in drug approval rates over the past decades …
3D Printing of Tissue Engineered Constructs for In Vitro Modeling of Disease Progression and Drug Screening
Abstract 2D cell culture and preclinical animal models have traditionally been implemented
for investigating the underlying cellular mechanisms of human disease progression …
for investigating the underlying cellular mechanisms of human disease progression …