Humans require a plethora of higher cognitive skills to perform executive functions, such as
reasoning, planning, language and social interactions, which are regulated predominantly …

The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

We demonstrate through theoretical, empirical, and sociocultural evidence that the concept
of impulsivity fails the basic requirements of a psychological construct and should be …

The executive functions allow for purposeful, deliberate, and intentional interactions with the
world—attention and focus, impulse control, decision making, and working memory. These …

Abstract Muscarinic Designer Receptors Exclusively Activated by Designer Drugs
(DREADD) gated by clozapine-N-oxide (CNO) allow selective G-protein cascade activation …

Cognitive deficits in schizophrenia are among the core symptoms of the disease, correlate
with functional outcome, and are not well treated with current antipsychotic therapies. In …

Executive function allows us to interact with the world in a purposive, goal-directed manner.
It relies on several cognitive control operations that are mediated by different regions of the …

Background Premature responding is a form of motor impulsivity that preclinical evidence
has shown to predict compulsive drug seeking but has not yet been studied in humans. We …

The frontal cortex, especially the anterior cingulate cortex area (ACA), is essential for
exerting cognitive control after errors, but the mechanisms that enable modulation of …

There has been a fundamental failure to translate preclinically supported research into
clinically efficacious treatments for psychiatric disorders. One of the greatest impediments …