Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a
family of small conserved eukaryotic proteins that mediate membrane fusion between …

SNARE proteins and Sec1/Munc18 (SM) proteins constitute the core molecular engine that
drives nearly all intracellular membrane fusion and exocytosis. While SNAREs are known to …

Since the discovery of SNARE proteins in the late 1980s, SNAREs have been recognized as
key components of protein complexes that drive membrane fusion. Despite considerable …

Membrane fusion, one of the most fundamental processes in life, occurs when two separate
lipid membranes merge into a single continuous bilayer. Fusion reactions share common …

Intracellular membrane fusion is mediated in most cases by membrane-bridging complexes
of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) …

Soluble N-ethylmaleimide–sensitive factor attachment protein receptor (SNARE) proteins
drive membrane fusion by assembling into a four-helix bundle in a zippering process. Here …

Neurotransmitter release is governed by proteins that have homo-logs in most types of
intracellular membrane fusion, including the Sec1/Munc18 protein Munc18-1 and the …

During the priming step that leaves synaptic vesicles ready for neurotransmitter release, the
SNARE syntaxin-1 transitions from a closed conformation that binds Munc18-1 tightly to an …

The relevance of protein stability for biological function and molecular evolution is widely
recognized. Protein stability, however, comes in two flavours: thermodynamic stability, which …

Neurotransmission relies on synaptic vesicles fusing with the membrane of nerve cells to
release their neurotransmitter content into the synaptic cleft, a process requiring the …