Alzheimer's disease (AD) is an age-related devastating neurodegenerative disorder, which
severely impacts on the global economic development and healthcare system. Though AD …

Alzheimer's disease (AD) is an incurable neurodegenerative disease. Numerous studies
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …

Reductive stress (RS) is the counterpart oxidative stress (OS), and can occur in response to
conditions that shift the redox balance of important biological redox couples, such as the …

Free radicals and other so-called 'reactive species' are constantly produced in the brain in
vivo. Some arise by 'accidents of chemistry', an example of which may be the leakage of …

Neuronal activity is a high‐energy demanding process recruiting all neural cells that adapt
their metabolism to sustain the energy and redox balance of neurons. During …

We investigated oxidative stress in human postmortem frontal cortexfrom individuals
characterized as mild cognitive impairment (n= 8), mild/moderate Alzheimer disease (n= 4) …

There is increasing awareness of the ubiquitous role of oxidative stress in
neurodegenerative disease states. A continuing challenge is to be able to distinguish …

Amyloid-β (Aβ) plaque deposition can precede the clinical manifestations of dementia of the
Alzheimer type (DAT) by many years and can be associated with changes in brain …

It is now established that oxidative stress is one of the earliest, if not the earliest, change that
occurs in the pathogenesis of Alzheimer's disease (AD). Consistent with this, mild cognitive …

Mitochondrial dysfunction is a hallmark of amyloid‐beta (Aβ)‐induced neuronal toxicity in
Alzheimer′ s disease (AD). The recent emphasis on the intracellular biology of Aβ and its …