JC polyomavirus (JCPyV) is a human-specific polyomavirus that establishes a silent lifelong
infection in multiple peripheral organs, predominantly those of the urinary tract, of …

JC polyomavirus (JCPyV), a ubiquitous human pathogen, causes several devastating brain
diseases in immune‐compromised individuals. The most notable of these JCPyV …

Programmed cell death-1 (PD-1) receptor signaling dampens the functionality of T cells
faced with repetitive antigenic stimulation from chronic infections or tumors. Using …

Tissue-resident memory CD8 T (TRM) cells defend against microbial reinfections at mucosal
barriers; determinants driving durable TRM cell responses in non-mucosal tissues, which …

Type I interferons (IFNs) are pleiotropic cytokines with potent antiviral properties that also
promote protective T cell and humoral immunity. Paradoxically, type I IFNs, including the …

Immunization with radiation-attenuated sporozoites (RAS) shown to confer complete sterile
protection against Plasmodia liver-stage (LS) infection that lasts about 6 to 9 months in mice …

The mechanism by which DNA viruses interact with different DNA sensors and their
connection with the activation of interferon (IFN) type I pathway are poorly understood. We …

Advances in immune-mediated targeted therapies have proved to be a double-edged sword
for patients by highlighting the risk of iatrogenic infective complications. This has been …

ABSTRACT JC polyomavirus (JCPyV), a human-specific virus, causes the aggressive brain-
demyelinating disease progressive multifocal leukoencephalopathy (PML) in individuals …

Objective Natalizumab blocks α4‐integrin‐mediated leukocyte migration into the central
nervous system (CNS). It diminishes disease activity in multiple sclerosis (MS), but carries a …