The tumour suppressor p53 has a central role in the response to cellular stress. Activated
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …

The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53
gene alters its response pathway, and is central to the development of many cancers. The …

Abstract p53 is a transcription factor that suppresses tumor growth through regulation of
dozens of target genes with diverse biological functions. The activity of this master …

The extent to which transcription factors read and respond to specific information content
within short DNA sequences remains an important question that the tumor suppressor p53 is …

The p53 tumour suppressor is modified through mutation or changes in expression in most
cancers, leading to the altered regulation of hundreds of genes that are directly influenced …

Even 30 years after its discovery, the tumor suppressor protein p53 is still somewhat of an
enigma. p53's intimate and multifaceted role in the cell cycle is mirrored in its equally …

Purpose: Mortality of patients with head and neck squamous cell carcinoma (HNSCC) is
primarily driven by tumor cell radioresistance leading to locoregional recurrence (LRR). In …

Large parts of mammalian genomes are transcriptionally inactive and enriched with various
classes of interspersed and tandem repeats. Here we show that the tumor suppressor …

Abstract p53 binds enhancers to regulate key target genes. Here, we globally mapped p53-
regulated enhancers by looking at enhancer RNA (eRNA) production. Intriguingly, while …

The tumor-suppressor p53 can induce various biological responses. Yet, it is not clear
whether it is p53 in vivo promoter selectivity that triggers different transcription programs …