Blood-brain barrier: from physiology to disease and back
The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …
pathogens from entering the brain. At the same time, the BBB regulates transport of …
Shared and distinct functions of type I and type III interferons
Type I interferons (IFNs)(IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties,
including induction by viral infection, activation of shared signaling pathways, and …
including induction by viral infection, activation of shared signaling pathways, and …
Type III interferons disrupt the lung epithelial barrier upon viral recognition
Viral infections of the lower respiratory tract are a leading cause of mortality. Mounting
evidence indicates that most severe cases are characterized by aberrant immune responses …
evidence indicates that most severe cases are characterized by aberrant immune responses …
Decoding type I and III interferon signalling during viral infection
EV Mesev, RA LeDesma, A Ploss - Nature microbiology, 2019 - nature.com
Interferon (IFN)-mediated antiviral responses are central to host defence against viral
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …
Claudin-5: gatekeeper of neurological function
Tight junction proteins of the blood–brain barrier are vital for maintaining integrity of
endothelial cells lining brain blood vessels. The presence of these protein complexes in the …
endothelial cells lining brain blood vessels. The presence of these protein complexes in the …
The dynamic blood–brain barrier
With the endothelium as its central unit, the blood–brain barrier (BBB) is a complex
multicellular structure separating the central nervous system (CNS) from the systemic …
multicellular structure separating the central nervous system (CNS) from the systemic …
[HTML][HTML] Interferon-λ mediates non-redundant front-line antiviral protection against influenza virus infection without compromising host fitness
Lambda interferons (IFNλs) or type III IFNs share homology, expression patterns, signaling
cascades, and antiviral functions with type I IFNs. This has complicated the unwinding of …
cascades, and antiviral functions with type I IFNs. This has complicated the unwinding of …
Type III interferons produced by human placental trophoblasts confer protection against Zika virus infection
A Bayer, NJ Lennemann, Y Ouyang, JC Bramley… - Cell host & …, 2016 - cell.com
During mammalian pregnancy, the placenta acts as a barrier between the maternal and fetal
compartments. The recently observed association between Zika virus (ZIKV) infection during …
compartments. The recently observed association between Zika virus (ZIKV) infection during …
Interferon-λ: immune functions at barrier surfaces and beyond
When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …
Biochemistry and molecular biology of flaviviruses
Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile,
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …