SUMMARY DNA repair and DNA damage tolerance machineries are crucial to overcome
the vast array of DNA damage that a cell encounters during its lifetime. In this review, we …

Our concept of a stable genome is evolving to one in which genomes are plastic and
responsive to environmental changes. Growing evidence shows that a variety of …

The structural features that enable replicative DNA polymerases to synthesize DNA rapidly
and accurately also limit their ability to copy damaged DNA. Direct replication of DNA …

Simple Summary The kynurenine pathway has two main physiological roles:(i) it protects
specific organs such as the eyes and placenta from strong immune reactions and (ii) it …

Genomic instability underlies many cancers and generates genetic variation that drives
cancer initiation, progression, and therapy resistance. In contrast with classical assumptions …

“Replicative stress” is one of the main factors underlying neoplasia from its early stages.
Genes involved in DNA synthesis may therefore represent an underexplored source of …

Special mechanisms of mutation are induced in microbes under growth-limiting stress
causing genetic instability, including occasional adaptive mutations that may speed …

DNA damage is a constant source of stress challenging genomic integrity. To ensure faithful
duplication of our genomes, mechanisms have evolved to deal with damage encountered …

DNA damaging chemotherapy is the first line of treatment for certain cancers, but its
longterm success is often marred by the eventual acquisition of chemoresistance. Other …

A significant barrier to effective cancer therapy is the development of resistance to the drugs
utilised. Standard chemotherapeutic regimens typically contain genotoxic agents, designed …