Cognitive ageing research examines the cognitive abilities that are preserved and/or those
that decline with advanced age. There is great individual variability in cognitive ageing …

The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …

In an aging population with increasing incidence of dementia and cognitive impairment,
strategies are needed to slow age-related decline and reduce disease-related cognitive …

There is an increasing role for biological markers (biomarkers) in the understanding and
diagnosis of neurodegenerative disorders. The application of imaging biomarkers …

Elevated hippocampal activation is observed in conditions that confer risk for Alzheimer's
disease, including amnestic mild cognitive impairment (aMCI). Studies in relevant animal …

Imaging has played a variety of roles in the study of Alzheimer disease (AD) over the past
four decades. Initially, computed tomography (CT) and then magnetic resonance imaging …

In this review, we focus on the potential role of the γ-aminobutyric acidergic (GABAergic)
system in age-related episodic memory impairments in humans, with a particular focus on …

During development, the healthy human brain constructs a host of large-scale, distributed,
function-critical neural networks. Neurodegenerative diseases have been thought to target …

There are declines with age in speed of processing, working memory, inhibitory function,
and long-term memory, as well as decreases in brain structure size and white matter …

Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a longitudinal multisite
observational study of healthy elders, mild cognitive impairment (MCI), and Alzheimer's …